kxyj July 6, 2016, 10:07 a.m.
报告题目：Modulating Biological Responses through Interfacial Materials Engineering
工作单位：ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia. E-mail: email@example.com
报告摘要：The design and assembly of responsive materials underpins the development of particle carriers for biomedical applications. This presentation will detail various assembly strategies and chemistries to generate multifunctional and responsive particles. Recent studies on the development of nanostructured polymer particles for efficient cargo encapsulation, triggered release and antibody-mediated targeting will be highlighted. Examples on the application of these particles loaded with oligonucleotides and peptides to stimulate immune responses will be given. It will be shown that engineered particles with well-controlled physicochemical properties can be used to uncover several key principles that govern particle-cell interactions. For example, redox-responsive capsules associate with cells in a time-dependent manner, which is mediated by the exofacial thiols on cell membranes, and during endocytosis, the particles distort in shape and accumulate in lysosomal compartments. Furthermore, the role of shape of engineered particles on cellular interactions will be discussed. The assembly of organic ligands with metal ions will also be presented, highlighting metal-ligand complexation as a facile approach to generate particles that can disassemble under cellular conditions. It is expected that such engineered particle systems represent a class of novel materials for therapeutic delivery as well as an interesting paradigm to attain detailed knowledge of complex nano-bio interactions. This knowledge may aid in the rational design of nanoengineered materials (beyond particle systems) for biological applications.
专家简介：Frank Caruso is a professor and an ARC Australian Laureate Fellow at The University of Melbourne. He is also Deputy Director of the ARC Centre of Excellence on “Convergent Bio-Nano Science and Technology”. He received his PhD degree in 1994 from The University of Melbourne, and from 1994-1997 was at the CSIRO Division of Chemicals and Polymers in Melbourne. He was an Alexander von Humboldt Research Fellow and group leader at the Max Planck Institute of Colloids and Interfaces (Berlin, Germany) from 1997–2002. From 2003-2012 he was an ARC Federation Fellow at The University of Melbourne. He has published over 390 peer-reviewed papers. He is one of Thomson Reuters’ Highly Cited Researchers (top 20 in materials science) and was on Thomson Reuters’ 2014 list of World's Most Influential Scientific Minds. He is an Editor of Chemistry of Materials and on the Editorial Advisory Boards of ten other journals. He was elected a Fellow of the Australian Academy of Science in 2009. He received the inaugural 2012 ACS Nano Lectureship Award (Asia/Pacific) for global impact in nanoscience and nanotechnology, the 2013 Australian Museum CSIRO Eureka Prize for Leadership in Science and the 2014 Victoria Prize for Science and Innovation.