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    中国山东省济南市山大南路27号
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导师风采

【个人简介】

姓名:          王瑶

出生年月:   198410

学历:       博士研究生

职称:          教授(博士生导师)

单位:          有机化学研究所

研究方向:  有机合成方法学研究、天然产物全合成以及其结构导向的化学生物学研究

地址:          山东省济南市山大南路27号新化学楼404

电话:           0531-88361558    

Email:          yaowang@sdu.edu.cn  

【学习及工作经历】

教育经历:
2002.9-2006.6   兰州大学 化学与化工学院 化学国家基地班 学士
2006.9-2012.6   兰州大学 功能有机分子化学国家重点实验室 有机化学 博士
工作经历:
2011.1-2012.12 兰州大学 优博计划选拔留任功能有机分子化学国家重点实验室
2013.1-2015.8   德国马普分子生理学研究所 洪堡学者
2015.9-              山东大学 化学与化工学院 教授

【主讲课程】

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【研究领域和兴趣】

(1)不对称催化
a. 不对称超分子过渡金属催化
b. 不对称超分子有机催化
(2)具有重要生理活性天然产物全合成及其结构导向的化学生物学研究

 

【主要论著】

26.   Zhi-Long Jia, Yao Wang*, Guo-Qiang Xu and Peng Fei Xu*, Kinetic Resolution via Supramolecular Iminium Catalysis: Multiactivation Enables the Asymmetric Synthesis of β-Aryl Substituted Aldehydes and Densely Functionalized Cyclohexanes

Chem. Commun. 2017, DOI: 10.1039/C7CC01625E.

25.   Zhi-Long Jia, Yao Wang, Chuan-Gang Zhao,Xiao-Hai Zhang, Peng-Fei Xu*, Highly Enantioselective Construction of Hajos-Wiechert Ketone Skeletons via an Organocatalytic Vinylogous Michael/Stetter Relay Sequence. 

Org. Lett. 2017, DOI:10.1021/acs.orglett.7b00767.

24.  Liang-Jie Zhang, Yao Wang, Xiu-Qin Hu, Peng-Fei Xu, Hydrogen-Bonding Network Promoted [3+2] Cycloaddition: Asymmetric Catalytic Construction of Spiro-pseudoindoxyl Derivatives.

Chem. Asian J. 2016,11, 834-838.

23.  Tian-YangYu, Hao Wei, Yong-Chun Luo, Yao Wang, Zhu-Yin Wang and Peng-Fei Xu, PPh3O as an Activating Reagent for One-Pot Stereoselective Syntheses of  Di-and Polybrominated Esters from Simple Aldehydes.

J. Org.Chem. 2016, 81, 2730–2736.

22.   Yao Wang, Hong Lu,Peng-Fei Xu*, Asymmetric Catalytic Cascade Reactions for Constructing Diverse Scaffoldsand Complex Molecules.

Acc. Chem. Res. 2015, 48, 1832-1844.

21.   Yao Wang, Peng-Fei Xu, “Application of Oganocatalytic Cascade Reactions in Natural Products Synthesisand Drug Discovery” in: Catalytic Cascade Reactions.

Wiley-VCH, 2014.

20.   Yun Gu#,Yao Wang#, Yong-Min Liang and Peng-Fei Xu*, Rationally Designed Multifunctional Supramolecular Iminium Catalysis: the Direct Vinylogous Michael Addition with Unmodified Linear Dienol Substrates.

Angew. Chem. Int. Ed.  2014, 53, 14128–14131.(Highlighted by Synfacts )

(#:Co-first author.).

19.    Yao Wang, Jonathan O. Bauer, Carsten Strohmann and Kamal Kumar*, A Bioinspired Catalytic Oxygenase Cascade to Generate Complex Oxindoles.

Angew. Chem. Int. Ed.  2014, 53, 7514–7518.

18.   Yong-Long Zhao, Yao Wang, Jian Cao, Yong-Ming Liang, and Peng-Fei Xu*, Organocatalytic Asymmetric Michael–Michael Cascade for the Construction of Highly Functionalized N-Fused Piperidinoindoline Derivatives.

Org. Lett. 2014, 16, 2438-2441.

17.   Tian-Yang Yu, Yao Wang, Xiu-Qin Hu and Peng-Fei Xu*, Triphenylphosphine Oxide-Catalyzed Stereoselective Poly- and Dibromination of Unsaturated Compounds.

Chem. Commun. 2014, 50, 7817-7820.

16.   Tian-Yang Yu#,Yao Wang# and Peng-Fei Xu*, An Unusual Triphenylphosphine Oxide Catalyzed Stereoselective 1,3-Dichlorination of Unsaturated Ketoesters.

Chem.-Eur. J. 2014, 20, 98–101.

(#:Co-firstauthor).

15.   Hong-Bo Zhang, Yao Wang, Yun Gu and Peng-Fei Xu*, Lewis- and Brønsted-Acid Cooperative Catalytic Radical Coupling of Aldehydes and Azodicarboxylate.

RSC Adv. 2014, 4, 27796-27799.

14.  Dan-Dan Tang, Yao Wang,Jun-Ru Wang and Peng-Fei Xu*, Phosphine-Mediated Synthesis of Trifluoromethyl Substituted Pyrroles Using TFAA as the CF3 Source.

Tetrahedron Lett. 2014, 30, 4133–4135.

13. Yong-Long Zhao#,Yao Wang#, Xiu-Qin Hu and Peng-Fei Xu*, Merging organocatalysis with transition metal catalysis and using O2 as theoxidant for enantioselective C–H functionalization of aldehydes.

Chem. Commun. 2013, 49, 7555-7557.

 (#:Co-first author).

12. Yao Wang, Tian-YangYu, Hong-Bo Zhang, Yong-Chun Luo and Peng-Fei Xu*, Hydrogen-Bond-Mediated Supramolecular Iminium Ion Catalysis.

Angew. Chem.Int. Ed.  2012, 51, 12339–12342.

(Highlighted by Synfacts and Chin. J. Org. Chem.)

11. Yao Wang, Yong-Chun Luo, Hong-Bo Zhang and Peng-Fei Xu*, Concise Construction of the Tetracyclic Core of Lycorine-Type Alkaloids and the Formal Synthesis of a-Lycorane Based on Asymmetric Bifunctional Thiourea-Catalyzed Cascade Reaction.

Org. Biomol. Chem. 2012, 10, 8211–8215.

10. Cheng-Yong Jin, Yao Wang, Yao-Zong Liu, Chao Shen and Peng-Fei Xu*, Organocatalytic AsymmetricMichael Addition of Oxindoles to Nitroolefins for the Synthesis of 2, 2-Disubstituted Oxindoles Bearing Adjacent Quaternary and Tertiary Stereocenters.

J. Org. Chem. 2012, 77, 11307–11312.

9. Zhen-Xin Jia,Yong-Chun Luo, Yao Wang Liang Chen, Peng-Fei Xu* and Binghe Wang, Organocatalytic aza-Michael-Michael Cascade Reactions: A Flexible Approach to Synthesize 2,3,4-Trisubstituted Tetrahydroquinolines.

Chem.-Eur. J. 2012, 18, 12958–12961.

8. Yao Wang, Yong-Chun Luo, Xiu-Qin Hu, and Peng-Fei Xu*, A Powerful Cascade Approach for Expeditious Synthesis of Trifluoromethylated Furans.

Org. Lett. 2011, 13, 5346–5349. (Highlighted by Synfacts)

7. De-Feng Yu, Yao Wang and Peng-Fei Xu*, Diastereo- and Enantioselective Synthesis of a Novel Tetracyclic Ring System via an Organocatalytic One-Pot Reaction.

Adv. Synth. Catal. 2011, 353, 2960–2965.

6. De-Feng Yu, Yao Wang and Peng-Fei Xu*, Oganocatalytic Enantioselective Multicomponent Cascade Reaction: Facile Access to Tetrahydropyridines with C3 All-Carbon Quaternary Stereocenters.

Tetrahedron 2011, 67, 3273–3277.

5. Yao Wang, De-Feng Yu,Yao-Zong Liu, Hao Wei, Yong-Chun Luo, Darren J. Dixon and Peng-Fei Xu*, Multiple-Organocatalyst-Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted Piperidines.

Chem.-Eur. J. 2010, 16, 3922–3925.

4. Yong-Chun Luo,Huan-Huan Zhang, Yao Wang and Peng-Fei Xu*, Synthesis of a-Amino Acids Based on Chiral Tricycloiminolactone Derived from Natural (+)-Camphor.

Acc. Chem. Res. 2010, 43, 1317–1330.

3. Hao Wei, Yao Wang, Bing Yue and Peng-Fei Xu*, Synthesis of Substituted 1,2-Dihydropyridines from Propargyl Vinyl Ethers and Allenic Vinyl Ethers by Gold-Catalyzed Claisen Rearrangement and 6π-Aza-electrocyclization.

Adv. Synth. Catal. 2010, 352, 2450–2454.

2. Yao Wang, Rong-GangHan, Yong-Long Zhao, Shu Yang, Peng-Fei Xu* and Darren J. Dixon*, Asymmetric Organocatalytic Relay Cascades: Catalyst-Controlled Stereoisomer Selection in the Synthesis of Functionalized Cyclohexanes.

Angew. Chem. Int. Ed.  2009, 48, 9834–9838.

(Highlighted by Synfacts and Chin. J. Org. Chem.)

1. Rong-Gang Han, Yao Wang, Yu-Ye Li, and Peng-Fei Xu*, Proline-Mediated Enantioselective Construction of Tetrahydropyridines via a Cascade Mannich /Intramolecular Cyclization Reaction.

Adv. Synth. Catal. 2008, 350, 1474–1478.

 


【科研项目】

国家自然科学基金(青年基金)                     在研、主持

“齐鲁青年学者”特聘教授科研启动经费      在研、主持

【科研成果】

甘肃省科技进步一等奖 2014

洪堡科研奖学金 2013

甘肃省自然科学一等奖 2010

"The Excellent Poster Award" of the 11th Tetrahedron Symposium 2010

宝钢奖学金 2010



 

 

【所获专利】

 许鹏飞,王瑶,胡秀琴, 一种合成含三氟甲基呋喃化合物的方法. Granted No.: CN 102344425 B.

 

【联合培养情况】

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【拟招收研究生情况】

 欢迎对有机化学化学生物学感兴趣的本科生、硕士生博士生和博士后加入本课题组。 

 

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