• 电话:0531-88364464
  • 传真:0531-88564464
  • 地址:
    中国山东省济南市山大南路27号
  • 邮编:250100

导师风采

【个人简介】

 姓名    翟淑梅
性别      女
出生日期  1977-02-11
学历      博士
职称     副教授(硕导)
研究类别:分析化学
工作单位:分析化学所
办公室:老晶体所227室
电话:0531-88364681
E-mail:smzhai@sdu.edu.cn
                                                                                                                                                                                                                                                                                      
                                                                                                                                                                                                                                                                                                                                                


【学习及工作经历】

2005年12月毕业于山东大学生命科学学院,获理学博士学位

2005/12–2015/09,山东大学,化学与化工学院,讲师
2007/03–2010/05,山东大学,药学院,博士后
2008/10–2009/10,美国Barbara Ann Karmanos 癌症研究中心,访问学者
2015/09-至今, 山东大学,化学与化工学院,副教授

 

 





【主讲课程】

仪器分析实验
无机及分析实验
物理化学实验


【研究领域和兴趣】

小分子化合物抗癌活性及其机制分析;
纳米材料生物效应分析 
                                                                                                


【主要论著】

  

19. Li F, Zhou XF, Zhou HY, Jia JB, Li LW, Zhai SM* and Yan B*. Reducing Both Pgp Overexpression and Drug Efflux with Anti-Cancer Gold-Paclitaxel Nanoconjugates. Plos One, 2016,11(7), e0160042.

18. Mu Y, Liu YJ, Xiang JB, Zhang Q, Zhai SM, Russo DP, Zhu H, Bai X, Yan B*. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor. Cell Death Dis., 2016, 7: e2143.

17. Zhang CK#, Zhai SM#, Wu L, Bai YH, Jia JB, Zhang Y, Zhang B, Yan B* Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles. Plos One2015, 10(4): e0122591.

16. Cui GX, Xin Y, Jiang X, Dong MQ, Li JL, Wang P; Zhai SM; Dong YC, Jia JB, Yan B* Safety Profile of TiO2-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation. Int. J. Mol. Sci., 2015, 16(11),27721-27729.

15. Zhang CK#, Zhai SM#, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B*. Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death Dis., 2014, 5, e1138.

14. Jiang CJ, Jia JB, Zhai SM*. Mechanistic understanding of toxicity from nanocatalysts. Int. J. Mol. Sci., 2014, 15, 13967-13992.

13. Wu L, Zhang Y, Zhang CK, Cui XH, Zhai SM, Liu Y, Yan B*. Tuning Cell Autophagy by Diversifying Carbon Nanotube’s Surface Chemistry. ACS Nano, 2014, 8(3): 2087-2099.

12. Zhang RN, Pan XH, Li F, Lin Z, Zhai SM, Mu QX, Liu JF, Qu GB, Jiang GB, Yan B.* Cell Rescue by Nano-Sequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct. Environ. Sci. Technol., 2014, 48(3):1984-92.

11. Liu AJ, Zhai SM, Zhang B, Yan B.* Analytical Strategies for Real-Time and Non-Invasive Tracking of Carbon Nanomaterials in vivo. TRAC-Trend Anal. Chem., 2013, 48, 1-13.

10. Zhang Q, Zhai SM, Li LW, Li X, Jiang CJ, Zhang CK, Yan B*. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model. J Pharmacol Sci., 2014;126(1):66-76.

9. Zhai SM, Gao Q, LiuXX , Sui ZH, Zhang JR* .Overexpression of a Zea mays phospholipase C1 gene enhances drought tolerance in tobacco in part by maintaining stability in the membrane lipid composition, Plant Cell Tiss. Org., 2013, 115: 253-262.

8. Liu XX, Zhai SM, Zhao YJ, Sun BC, Liu C, Yang AF, Zhang JR, Overexpression of the phosphatidylinositol synthase gene (ZmPIS) conferring drought stress tolerance by altering membrane lipid composition and increasing ABA synthesis in maize. Plant Cell Environ., 2013, 36(5): 1037-1055.

7. Zhou HY, Zhang Y, Su GX, Zhai SM, Yan B*, Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation. RSC Advances, 2013, 3(44), 21596-21603.

6. Zhang Q, Zhai SM, Li LW, Li XE, Zhou HY , Liu AF, Su GX, Mu QX, Du YH , Yan B*. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochem. Pharmacol., 2013, 86: 351–360.

5. Zhai SM#, Gao Q#, Xue HW, Sui ZH, Yue GD, Yang AF, Zhang JR*. Overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance, Planta, 2012, 235(1), 69-84.

4. Wang F#, Zhai SM#, Liu XJ, Li LW, Wu S, Dou QP*, Yan, B.* A Novel Dithicarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Depentent Proteasome-Inhibitory and Apoptosis-Inducing Activity in Human Breast Cancer Cells. Cancer Lett., 2011, 300(1), 87-95.

3. Zhai SM, Yang L, Cui Q, Sun Y, Dou Q,* Yan, B.* Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxylquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells. J Biol. Inorg. Chem., 2010,15(2), 259-269.

2. Zhang Q, Zhou HY, Zhai SM, Yan B*. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities. Curr Pharm Des. 2010; 16(16):1826-42.

1. Zhou HY, Wu SH, Zhai SM, Liu, AF, Sun Y, Li RS, Zhang Y, Ekins S, Swaan PW, Fang, BL. Zhang B, Yan B.* Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells. J. Med. Chem. 2008, 51 (5), 1242-1251 

               

 




【科研项目】

主持的科研项目
1.国家自然科学基金青年基金,2010.01-2012.12
2.山东大学资助创新基金,2010.06-2012.12
3.山东省自然科学基金面上项目,2014.12-2017.12
4.中国博士后科学基金第58 批面上资助
5.中国博士后科学基金第九批特别资助
6.国家自然基金面上项目,2017.01-2020.12





 




【科研成果】

【所获专利】

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【联合培养情况】

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【拟招收研究生情况】

   2017年拟招收硕士研究生1-2名                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  

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