• 电话:0531-88364464
  • 传真:0531-88564464
  • 地址:
    中国山东省济南市山大南路27号
  • 邮编:250100

导师风采

【个人简介】

姓名: 高洪银

出生年月:  19837

学历:博士研究生

职称:   “齐鲁青年学者特聘教授(博士生导师)

单位:    有机化学研究所

研究方向现代有机合成方法学研究、活性药物小分子(中间体)合成及生物活性探究

地址:  山东省济南市山大南路27号新化学楼525

电话:0531-88361236

手机:13064095206

Email:  hygao@sdu.edu.cn

【学习及工作经历】

2016.11 -                 山东大学    教授

2015.05 - 2016.10   美国莱斯大学  博士后   导师:Prof. Laszlo Kurti

2012.01 - 2015.05   美国德州大学西南医学中心  博士后    导师:Prof. Laszlo Kurti

2011.09 - 2011.12    北京大学深圳研究生院    研究助理    导师:赵劲教授

2006.09 - 2011.07    华东师范大学    博士    导师:张俊良教授

2001.09 - 2006.07    泰山学院     学士    导师:孙一峰教授


【主讲课程】

【研究领域和兴趣】

1)多官能团取代的药物活性小分子(中间体)的设计、合成及生物活性探究;

2)新型官能团化反应试剂的设计、开发与应用;

3)金属催化的串联反应;

4)自由基化学等。


【主要论著】

 

1.     Zhe Zhou, Zhiwei Ma, Nicole Erin Behnke1, Hongyin Gao, László Kürti.* “Non-​Deprotonative Primary and Secondary Amination of (Hetero)​Arylmetals.”  J. Am. Chem. Soc. 2017, 139, 115-118.(Link)

 

2.     Hongyin Gao, Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke1, Daniel H. Ess*, László Kürti.* “Rapid Heteroatom-Transfer to Arylmetals Utilizing Multifunctional Reagent Scaffolds.”Nature Chemistry 2017, 9, 681-688. (Link) This paper was highlighted by C&EN (2016, 94 (48), 7) <Link> and X-Mol <Link> on December 7th, 2016.

 

3.     Hongyin Gao,# Qing-Long Xu, # Craig Keene, Muhammed Yousufuddin, Daniel H. Ess, László Kürti.*Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.”Angew. Chem. Int. Ed. 2016, 55, 566-571. (Hot Paper) (Link) This paper was highlighted by C&EN (Chemical and Engineering News 2015, 93(48), 37.).<Link> # Contributed equally.

 

4.     Hongyin Gao, Qing-Long Xu, Craig Keene, László Kürti.*“Scalable, Transition-Metal-Free Direct Oxime O-Arylation: Rapid Access to O-Arylhydroxylamines and Substituted Benzo[b]furans.” Chem. Eur. J. 2014, 20, 8883-8887. (Link)

 

5.     Hongyin Gao, Qing-Long Xu, Muhammed Yousufuddin, Daniel H. Ess, László Kürti.*Rapid Synthesis of Fused N-Heterocycles by Transition-Metal-Free Electrophilic Amination of Arene C-H Bonds.” Angew. Chem. Int. Ed. 2014, 53, 2701-2705. (Hot Paper) (Link) This paper was highlighted by SYNFACTS (Synfacts 2014, 10(4), 351.). <Link>

 

6.     Jawahar L Jat, Mahesh P. Paudyal, Hongyin Gao, Qing-Long Xu, Muhammed. Yousufuddin, Deepa Devarajan, Daniel H. Ess, László Kürti,* J. R. Falck.* Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins.” Science 2014, 343, 61-65.(Link) This paper was highlighted by Science, <Link> Nature Chemistry,<Link>  Angewandte Chemie International Edition, <Link> Chemical and Engineering Newsand Chemistry World.

 

7.     Qing-Long Xu, Hongyin Gao, Daniel H.Ess, László Kürti.* Aerobic, Transition-Metal-Free, Direct and Regiospecific Mono-α-Arylation of Ketones: Synthetic Studies and Mechanism by DFT Calculations.” J. Am. Chem. Soc. 2013, 135, 14048-14051.(Link)

 

8.     Gong-Qiang Li, Hongyin Gao, Craig Keene, Michael Devonas, Daniel H. Ess,László Kürti.* Organocatalytic Aryl-Aryl Bond-Formation: An Atroposelective [3,3]-Rearrangement Approach to BINAM Derivatrives.” J. Am. Chem. Soc. 2013, 135, 7414-7417.(Link)

 

9.      Hongyin Gao, Daniel H. Ess, M. Yousufuddin,  László Kürti.* Transition-Metal-Free Direct Arylation: Synthesis of Halogenated 2-Amino-2’-Hydroxy-1,1’-Biaryls and Mechanism by DFT Calculations.”  J. Am. Chem. Soc. 2013, 135, 7086-7089. (Cover Paper)(Link) This paper was highlighted by JACS (J. Am. Chem. Soc. 2013, 135, 7081.),<Link>  SYNFACTS (Synfacts 2013, 9(8), 879.) <Link> and C&EN (Chemical and Engineering News 2013, 91(21), 40.).<Link>

 

10.  Hongyin Gao, Junliang Zhang.* Cationic Rhodium(I)-Catalyzed Regioselective Tandem Hetero- cyclization/ [3+2] Cycloaddition of 2-(1-Alkynyl)-2-alken-1-ones with Alkynes.Chem. Eur. J. 2012, 18, 2777-2782.(Link)

 

11.  Hongyin Gao, Xingxing Wu, Junliang Zhang.*Gold(I)-Catalyzed Highly Diastereo-selective Tandem Heterocyclization/[3+2] Cycloaddition: Synthesis of Highly Substituted Cyclopenta[c]furan.”Chem. Eur. J. 2011,17, 2838-2841.(Link)

 

12.  Hongyin Gao, Xingxing Wu, Junliang Zhang.*Exo/endo selectivity-control in Lewis-acid catalyzed tandem hetero-cyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkyn-yl)-2-alken-1-ones and 1,3-diphenylisobenzofuran.” Chem. Commun. 2010, 46, 8764-8766. (Link)

 

13.  Hongyin Gao, Xiaoli Zhao, Yihua Yu, Junliang Zhang.* “Highly Substituted Furo [3,4-c]azepines by Gold(I)-Catalyzed Diastereoselective Tandem Double Heterocyclizations and 1,2-Alkyl Migration.” Chem. Eur. J. 2010, 16, 456-459.(Link) This paper was highlighted by SYNFACTS ( Synfacts 2010, 3, 285.).<Link>

 

14.  Hongyin Gao, Junliang Zhang. “A Dramatic Substituent Effect in Silver(I)-Catalyzed Regioselective Cyclization of ortho-Alkynylaryl Aldehyde Oxime Derivatives.” Adv. Synth. Catal. 2009, 351, 85-88.(Link)

 

15.  Hongyin Gao, Junliang Zhang.“Catalytic Cascade Reactions”, Chap 6, 225-282. First Edition. Edited by Peng-Fei Xu and Wei Wang. John Wiley & Sons, Inc. 2014.

 

【科研项目】

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【科研成果】

【所获专利】

1.     Hongyin Gao, László Kürti, Zhe Zhou.Amination and Hydroxylation of Arylmetal Compounds.” (US Provisional filed on 5/5/2016 by Rice University; IP Application # 62/366,483).

2.     Hongyin Gao, László Kürti.Transition Metal Free Methods of Synthesis of Biaryl Compounds.” (US Provisional patent filed on 11/9/2015 by Rice University. Now Converted: PCT/US2016/061628).

3.     Carolyn L. Cannon, Hongyin Gao, László Kürti, Kush Nimish Shah, Parth Nimish Shah.Biaryl Compounds as Antimicrobial and Chemotherapeutic Agents.” (US Provisional patent filed on 9/16/2015 jointly by Rice University and Texas A&M University. Now Converted: PCT/US2016/061607).

【联合培养情况】

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【拟招收研究生情况】

热烈欢迎对有机化学感兴趣的本科生、硕士生、博士生和博士后加入本课题组!


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