• 电话:0531-88364464
  • 传真:0531-88564464
  • 地址:
    中国山东省济南市山大南路27号
  • 邮编:250100

导师风采

【个人简介】

杨国生博士,教授 
第四、五届中国色谱学会理事,山东省化学化工学会色谱专业委员会委员。第四届《分析试验室》编辑委员会委员
 
电话:0531-88364464 

 

【学习及工作经历】

1979.9--1983.6 于中山大学化学系,获学士学位。
1987.9--1990.6 于河北大学理化分析中心,获理学硕士学位。
1992.9--1995.6 于南开大学化学系,获理学博士学位
1995年7月--今  山东大学化学学院任教。
1999年5月--2001年2月在山东大学理论化学研究所进行博士后研究。
2000年2月--2000年6月受国家基金委和德国DFG资助在德国Tübingen大学与B. Koppenhoefer教授合作,进行药物中间体的合成及手性药物分离研究。
2001年2月—2001年8月在法国Bordeaux第一大学与G. Felix教授进行多环芳烃分离研究。
2002年2月—2003年1月受西班牙教育部资助,在西班牙Almeria大学与P. Parrilla教授进行农药残留分析和农药对映体分离研究。

【主讲课程】

 先后讲授过基础课“无机及分析化学”、“分析化学”、大四选修课“色谱技术”、通识课“化学与现代社会”和硕士生学位课“色谱及联用技术”。

【研究领域和兴趣】

 GC-MS, GC-MS/MS, LC-MS/MS。液相色谱手性固定相合成和手性色谱分离机理研究,ESI手性识别研究。天然药物有效成分的分离分析,农药残留、兽药残留分析,环境污染物分析

【主要论著】

  
  • 2000年以来发表的论文:

    (1) 杨国生,严波,雷林,王文刚,刘成卜,三唑稀醇手性识别的分子力学研究,高等学校化学学报,20002111),1745-1747

    (2) Guo-Sheng YangMu-Bin HuangQin DaiRu-Yu Gao, Qin-Sun WangGao-LanLiInfluence of the structure ofOrganic Phosphonate Compounds on Chiral separation on the Pirkle Type ChiralStationary Phase, Chromatographia, 2001, 53, 93-95

    (3) Guo-Sheng Yang,Lan ZhouWei DuQin DaiGao-Lan LiG. Felix HPLC enantiomericseparation of o,o-dialkyl-2-2benzyloxycarbonyl- aminoarlmethyl- phosphonates oncellulose tris(3,5-dimethylphrnyl carbamate) and N-(3,5-dinitrobenzoyl) leucineCSPs,  J. Liq. Chrom. & Rel.Technol., 2001, 24(19), 3037-3048

    (4) 李高兰,黄幕斌,杨国生等,用薄层色谱法拆分手性芳香醇胺类药物,山东大学学报, 2001, 364429

    (5) 杜伟,杨国生,张强,郝爱友,B. Koppenhoefer,以环糊精为手性添加剂对药物对映体的毛细管电泳手性拆分,山东大学学报, 2001, 364433-438

    (6) Guo-Sheng YangLan ZhouWei DuGao-Lan LiP. Piedad Vazquez, A.Garrido FrenichEffect of the Structure ofOrganic Phosphonate Compounds on Chiral Separations on Derivatized CelluloseChiral Stationary Phase Chromatographia, 2002, 56(3/4) 143-145

    (7) 刘永军,刘成卜,杨国生,6, 7, 8, 9-四氢-吩嗪并[2, 3]C60衍生物的结构、电子光谱和二阶非线性光学性质的理论研究,结构化学, 2002, 21(2) 191

    (8) Guo-Sheng Yang,Wei DuLan ZhouP. Piedad Vazquez, A. Garrido FrenichJ. L. Martine Vidal, Hassan Y.Aboul-EneinInfluence of the alcoholic modifier on theenantioseparation of organophosphate derivatives on cellulosetris(3,5-dimethylphenylcarbamate) chiral stationary phase under normal phasemode, Anal. Lett., 2003,36(7) 1423-1435

    (9)Wei DuGuo-Sheng YangXin-Qiang WangShi-Ling YuanLan ZhouDong XuCheng-Bu Liu Enantioseparation of 15 organic phosphonate esters onthe cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase byHPLCTalanta2003, 60, 1187-1195

    (10) Guo-Sheng YangP. Piedad Vazquez, A. Garrido FrenichJ. L. Martine Vidal, Hassan Y.Aboul-EneinChiral Separation Of Organic Phosphonate Compounds OnCellulose CSPChiral Stationary Phese Under Reversed Phase Mode, Anal. Sci., 2003, 19,1157-1161

    (11) Guo-Sheng YangP. Piedad Vazquez, A. Garrido FrenichJ. L. Martine Vidal, Hassan Y. Aboul-EneinEnantioseparation of Organophosphonate Derivatives onAmylose Tris(3,5-Dimethylphenylcarbamate) Chiral Stationary Phase by HPLC, J.Liq. Chrom. & Rel. Technol., 2003, 26, 3073-3082

    (12) Guo-Sheng Yang,Shi-ling Yuan, Xian-Jie Lin, Zhong-Nan Qi, Cheng-Bu Liu, Guy Félix, Hassan Y. Aboul-EneinThe Study of p-p Interaction in High PerformanceLiquid Chromatography by Molecular Modeling, Anal. Lett., 2004, 37(3) 529 - 543

    (13) Guo-Sheng Yang,Piedad Parrilla Vázquez, Antonia Garrido Frenich, Jose L. Martínez Vidal,Hassan Y. Aboul-Enein, Chiral separation of several pyrethroids onpolysaccharide-based chiral stationary phases under normal and reversed phasemodes, J. Liq. Chrom. & Rel. Technol., 2004, 27, 1507–1521

    (14) Guo-Sheng Yang,Shi-Ling Yuan, Xian-Jie Lin, Zhong-Nan Qi, Cheng-Bu Liu, Hassan Y. Aboul-Enein,Guy Félix, study of chiral discrimination of organophosphonate derivatives onpirkle type chiral stationary phase by molecular modeling, Talanta2004, 64320325

    (15) Guo-Sheng Yang,Chang-Yu Zhan, Gui-Hua Fu, Piedad Parrilla Vazquez, Antonia Garrido Frenich,Jose L. Martinez Vidal, Hassan Y. Aboul-Enein, chiral separation of organicphosphonate compounds on polysaccharide-based chiral stationary phases,Chromatographia, 2004, 59, 631–635

    (16Guo-Sheng Yang, Piedad Parrilla Vázquez, Antonia GarridoFrenich, José Luis Martínez Vidal, Hassan Y. Aboul-Enein, Separation andSimultaneous Determination of Enantiomers of Tau-fluvalinate and Permethrin in DrinkingWater, Chromatographia, 2004, 60(9/10), 523-526

    (17) Hua-Bin Zou,Guo-Sheng Yang, Zheng-Ren Qin, Wen-Qiang Jiang, Ai-Qin Du,Hassan Y.Aboul-Enein, Progress in quality control of herbal medicine with IR fingerprintspectra, Anal. Lett., 2005, 38, 1457-1475

    (18) Guo-Sheng Yang,Dong-Mei Chen, Yong Yang, Bo Tang, Jing-Jing Gao, Hassan Y. Aboul-Enein,Bernhard Koppenhoefer, Separation of enantiomers of drugs by capillaryelectrophoresis with sulfated Na-salt β-Cyclodextrin as chiral agent, Chromatograpia,2005,62, 441–445

    (19) Huabin Zou, Guosheng Yang, Aiqin Du, JiurongYuan, Zhengran Qin, Yingying Xia and Hassan Y. Aboul-Enein,Combinational numeral fingerprint spectra of Glycyrrhiza and analysis of commonpeak ratio invariableness in HPLC, Biomed. Chromatogr., 2006, 20, 642–655)

    (20) Zilei Chen, HongZhang, Bing Liu, Guosheng Yang*, Hassan Y. Aboul-Enein, Wenbo Wang, RuiyanDing, Hongxia Du, Huidong LiDetermination of Herbicide Residues in Garlic by GC–MS,Chromatographia, 2007, 66, 887–891

    (21) Hong Zhang, ZileiChen, Guosheng Yang*, Wenzheng Wang, Xiuqing Li, Ruiju Li, Yuanjuan Wu,Microwave pretreatment and gas chromatography-mass speactrometry determinationof herbicide residues in onion, Food Chem., 2008,108, 332-328

    (22) Wei Zhou, BingLiu, Guo-Sheng Yang, Bernhard Koppenhoefer, Hassan Y. Aboul-Enein, Separationof the Enantiomers of Oxiranes by High Performance Liquid Chromatography onPolysaccharide-Based Chiral Stationary Phases, J. Liq. Chrom. & Rel.Technol., 2008,31, 2879 - 2891

    (23) Hua-Bin Zou, Guo-ShengYang, Bing Liu, Zhai Hong, Jiurong Yuan, Yingying Xia, Hassan Y. Aboul-Enein, Recognitionof Radix Paeoiae Alba Herbs (Fam. Ranunculaceae) with HPLCFingerprint Spectra, Anal.Lett., 2008, 41, 33093323

    (24) 陆玮洁,刘冰,邹华彬,张衡,张新玲,杨国生,茶叶1HNMR指纹图谱双指标序列分析,山东大学学报(理学版),2009, 44335-38

    (25) Lu Wei-jie, Zou Hua-bin, ZhangXin-ling, Yang Guo-sheng*, Hassan Y. Aboul-Enein, Study on 1HNMRFingerprint Spectra of Tea by Common and Variation Peak Ratio Dual-Index SequenceAnalysis Method, Anal. Lett.,2009, 42(14), 2244 - 2253

    (26) Bing Liu, Wei-JieLu, Guo-Sheng Yang*, Hassan Y. Aboul-Enein, The study of elution order inchiral separation of organic phosphonate esters by cellulose chiral stationaryphase in HPLC, J. Liq. Chrom. & Rel. Technol.,2009, 32(20) 2954-2960

    (27) 刘冰,陆玮洁,杨国生,遗传算法在烷基硝基苯酚类化合物的QSRR中的应用,山东大学学报(理学版)200944(9), 8-11

    (28) Lin-Juan Qu, HuiZhang, Jian-Hua Zhu, Guo-Sheng Yang*, Hassan Y. Aboul-Enein, Rapid determinationof organophosphorous pesticides in leeks by gas chromatography-triplequadrupole mass spectrometry, Food Chemistry, 2010, 122(1), 327-332

    (29) Hong Zheng, Li-GangDeng, Xiao Lu, Shan-Cang Zhao, Chang-Ying Guo, Jiang-Sheng Mao, Yu-Tao Wang, Guo-ShengYang*, Hassan Y. Aboul-Enein, UPLC-ESI-MS/MS Determination three typical β2-agonists in pork, Chromatograpia,2010, 72(1/2), 79-84

    (30) Ning-Ning Chen,Shan-Cang Zhao, Li-Gang Deng, Chang-Ying Guo, Jiang-Sheng Mao, Hong Zheng, Guo-ShengYang*, Xiao Lu, Hassan Y. Aboul-Enein, Determinationof five polyphenols by HPLC/DAD and discrimination of apple varieties, Chromatographia,2011,73(5/6), 595–598

    (31) Xiao Lu, HongZheng, Xiu-Qing Li, Xue-Xia Yuan, Hui Lid, Li-Gang Deng, Hong Zhang, Wen-ZhengWang, Guo-Sheng Yang*, Meng Meng, Ri-Mo Xi, Hassan Y. Aboul-Enein, Detection ofRactopamine Residues in Pork by Surface Plasmon Resonance-Based BiosensorInhibition Immunoassay, Food Chem., 2012, 130, 1061-1065

    (32) Lu–Ge Huo,Hui–Dong Li, Chang–Le Zhao, Wen–Bo Wang, Zi–Lei Chen, Rui–Yan Ding, Zhan Dong,Feng–En Wang, Guo–Sheng Yang*, Xiao Lu, Hassan Y. Aboul-Enein, TheDetermination of PCBs in Meat and Sea Food by GC-QqQ-MS/MS, Food Anal. Method, 2012,5(6),1481-1491

     (33) Hong–Xia Zhao, Shan–CangZhao, Li–Gang Deng, Jiang–Sheng Mao, Chang–Ying Guo, Guo–Sheng Yang*, XiaoLu, Hassan Y. Aboul-Enein, Rapid determination of organonitrogen,organophosphorus and carbamate pesticides in tea by ultra-high-performanceliquid chromatography-tandem mass spectrometry (UPLC-MS/MS), Food Anal. Method,2013, 6(2), 497-505

    (34) Bing Liu, Yong Zhou, Guo-Sheng Yang*, Hassan Y. Aboul-EneinThe Study Of SeparationOf Four Groups Organophosphonate Derivatives On N-(3,5-Dinitrobenzoyl)-L-Leucine–N-PropylamideStationary Phase By Molecular ModelingChirality, 2013, 25, 101–106

    (35) Hui–Dong Li, Lu–GeHuo, Wen–Bo Wang, Zi–Lei Chen, Ding Ruiyan, Fang Liping, Wang Fengen, Xiao Lu, Guo–ShengYang, Hassan Y. Aboul-Enein, The Determination of PAHs in Fish by GC-QqQ-MS/MSPoly. Arom. Comp., 2013,33, 97-107

    (36)Chang-Le Zhao, Rui-Yan Ding, Lu-Ge Huo, Hui-Dong Li, Zhan Dong, Feng-En Wang, Guo-ShengYang*, Xiao Lu, Hassan Y. Aboul-Enein, Determination of pesticide residues in green tea by gas chromatography-triple quadrupole mass spectrometry with solidphase extraction, J. AOAC Int., 2014, 97(4), 1001-1006

  • 【科研项目】

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    【科研成果】

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    【所获专利】

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    【联合培养情况】

     

  • 【拟招收研究生情况】

    每年拟招生全日制硕士研究生1-2名,在职攻读硕士学位研究生若干名。

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