• 电话:0531-88364464
  • 传真:0531-88564464
  • 地址:
    中国山东省济南市山大南路27号
  • 邮编:250100

导师风采

【个人简介】

  • 姓 名赵宝祥
    性 别
    出生日期1959-09-23
    学 历博士
    职 称教授  ( 博导 [聘任于2007])
    学术身份
    行政职务
    学术团体兼职
    研究类别有机化学 ::
    工作单位有机化学研究所 ::
    电 话0531-88366425
    传 真
    地 址
    E-mailbxzhao@sdu.edu.cn
     
  •  

【学习及工作经历】

  • 1978.10-1982.6 大连理工大学化学工程系学习(本科)
    1983.9-1986.6 大连理工大学研究生院精细化工系学习(硕士研究生)
    1986.7-1993.3 山东省化工研究院工作,工程师
    1994.10-1998.3 日本名古屋大学,博士研究生,获得应用化学专业工学博士学位
    1998.3-1999.9 山东大学化学院有机化学研究所,副教授
    1999.10-2000.7 德国柏林工业大学有机化学研究所博士后研究员
    2000.7-今 山东大学化学与化工学院有机化学研究所,教授
    2003.7-2004.6 韩国昌原大学合成化学研究所博士后研究员
     

【主讲课程】

  • 有机化学 (化学基地班,双语教学)

    有机化学实验,

    综合化学实验

    有机合成新方法(研究生学位必修课)

    合成化学(研究生必修课)

     

【研究领域和兴趣】

  • 有机合成 荧光探针 药物化学,杂环化学, 化学生物学 

【主要论著】

  • 2017

  • 1. Dong-Peng Li,Zhao-Yang Wang,Hao Su,Jun-Ying Miao* and Bao-Xiang Zhao*
    Fluorescence detection of endogenous bisulfite in liver cancer cells using an effective ESIPT enhanced FRET platform
    Chem. Commun.,2017, 53, 577-58.

  • 2. Shi-Li Shen,Xuan Zhao,Xiao-Fan Zhang,Xuan-Li Liu,Hao Wang,Yi-Ying Dai,Jun-Ying Miao and Bao-Xiang Zhao*
    A mitochondria-targeted ratiometric fluorescent probe for hypochlorite and its applications in bioimaging
    J. Mater. Chem. B, 2017, 5,289-295.

    3. Wen-Li Wu, Han-Lin Ma, Miao-Fei Huang,Jun-Ying Miao,Bao-Xiang Zhao*
    Mitochondria-targeted ratiometric fluorescent probe based on FRET for bisulfite
    Sensors and Actuators B 241 (2017) 239–244.

    4. Yan-Ru Zhang, Ying Liu, Xiao Feng, Bao-Xiang Zhao*
    Recent progress in the development of fluorescent probes for the detection of hypochlorous acid
    Sensors and Actuators B 240 (2017) 18–36.

    5. Wen-Li Wu, Xuan Zhao, Long-Long Xi, Miao-Fei Huang, Wen-Hui Zeng, Jun-Ying Miao*, Bao-Xiang Zhao*
    A mitochond ria-targetedfl uorescence probe for ratiometric detection of endogenous hypochlorite in the living cells
    Analytica Chimica Acta 950 (2017) 178-183.

  • 6. Shi-Li Shen, Jun-Ya Ning, Xiao-Fan Zhang, Jun-Ying Miao, Bao-Xiang Zhao*
    Through-bond energy transfer-based ratiometric fluorescent probe for the imaging of HOCl in living cells
    Sensors and Actuators B 244 (2017) 907–91

  • 7. Qiong Yuan, Zhi-Min Zhao, Yan-Ru Zhang, Le Su, Jun-Ying Miao, Bao-Xiang Zhao
    A lysosome-targeted ratiometric fluorescent probe for detection of hypochlorous acid in living cells
    Sensors and Actuators B 247 (2017) 736–741.

     2016

  • 1. Dong-Peng Li, Zhao-Yang Wang, Xiang-Jian Cao, Jie Cui, Xin Wang, Hao-Zhong Cui, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells,
    Chem. Commun., 52 (2016) 2760--2763.

    2. Xiao Feng, Tao Zhang, Jin-Ting Liu, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria,
    Chem. Commun. 52 (2016) 3131--3134.

    3. Wen-Li Wu,Zhao-Yang Wang, Xi Dai, Jun-Ying Miao & Bao-Xiang Zhao*,
    An effective colorimetric and ratiometric fluorescent probe based FRET with a large Stokes shift for bisulfite.
    Scientific Reports,6:25315 (2016).

    4. Yan-Ru Zhang, Zhi-Min Zhao, Jun-Ying Miao, Bao-Xiang Zhao*,
    A ratiometric fluorescence probe based on a novel FRET platform for imaging endogenous HOCl in the living cells,
    Sensors and Actuators B 229 (2016) 408–413.

    5. Xi Dai, Tao Zhang, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A ratiometric fluorescent probe with DNBS group for biothiols in aqueous solution,
    Sensors and Actuators B 223 (2016) 274-279.


    6. Xi  Dai, Zhao-Yang Wang, Zhi-Fang Du,Jun-Ying Miao,Bao-Xiang Zhao*,
    A simple but effective near-infrared ratiometric fluorescent probe for hydrazine and its application in bioimaging,
    Sensors and Actuators B 232 (2016) 369–374.

    7. Wen-Li Wu, Zhi-Min Zhao,Xi Dai, Le Su, Bao-Xiang Zhao,
    A fast-response colorimetric and fluorescent probe for hypochlorite and its real applications in biological imaging
    Sensors and Actuators B 232 (2016) 390–395

    8. Jie  Cui, Tao Zhang, Yi-Qing Sun, Dong-Peng Li, Jin-Ting Liu, Bao-Xiang Zhao,
    A highly sensitive and selective fluorescent probe for H2S detection with large fluorescence enhancement
    Sensors and Actuators B 232 (2016) 705–711,

    9. Dong-Peng Li, Jin-Feng Zhang, Jie Cui, Xiao-Feng Ma,  Jin-Ting Liu, Jun-Ying Miao,Bao-Xiang Zhao
    A ratiometric fluorescent probe for fast detection of hydrogen sulfide and recognition of biological thiols
    Sensors and Actuators B 234 (2016) 231–238

    10. Li-Jie  Zhang, Zhao-Yang Wang, Xiang-Jian Cao, Jin-Ting Liu, Bao-Xiang Zhao,
    An effective ICT-based and ratiometric fluorescent probe for sensing sulfite
    Sensors and Actuators B 236 (2016) 741–748

    11. Xiang-Jian Cao, Li-Na Chen, Xuan Zhang, Jin-Ting Liu, Ming-Yu Chen,Qiu-Rong Wu, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A NBD-based simple but effective fluorescent pH probe for imaging of lysosomes in living cells,
    Analytica Chimica Acta 920 (2016) 86-93.

    12. Ying Liu, Zhi-Min Zhao, Jun-Ying Miao*, Bao-Xiang Zhao*
    A ratiometric fluorescent probe based on boron dipyrromethene and rhodamine Forster resonance energy transfer platform for hypochlorous acid and its application in living cells,
    Analytica Chimica Acta 921 (2016) 77-83.

    13. Xi Dai, Zhi-Fang Du, Li-Hong Wang, Jun-Ying Miao, Bao-Xiang Zhao*
    A quick response fluorescent probe based on coumarin and quinone for glutathione and its application in living cells
    Analytica Chimica Acta 922 (2016) 64-70.

    14.Yan-Ru Zhang, Zhi-Min Zhao, Le Su, Jun-Ying Miao, Bao-Xian g Zhao*,
    A ratiometric fluorescence sensor for HOCl based on a FRET platform and application in living cells,
    RSC Adv., 6 (2016) 17059-17063.

     2015

  • 1. Yan-Ru Zhang,Ning Meng,Jun-Ying Miao* and Bao-Xiang Zhao*
    A Ratiometric Fluorescent Probe Based on a Through-Bond Energy Transfer(TBET)System for Imaging HOCl in Living Cells
    Chem. Eur. J. 2015, 21,19058–19063

  • 2. Shi-Li Shen,Xin-Peng Chen,Xiao-Fan Zhang,Jun-Ying Miao*, Bao-Xiang Zhao*
    A rhodamine B-based lysosomal pH probe
    J. Mater. Chem. B,2015, 3,919–925.

  • 3. Xiao-Fan Zhang,Tao Zhang,Shi-Li Shen,Jun-Ying Miao* and Bao-Xiang Zhao*
    A ratiometric lysosomal pH probe based on the naphthalimide–rhodamine system
    J. Mater. Chem. B, 2015, 3, 3260--3266.

  • 4. Xi Dai, Tao Zhang, Zhi-Fang Du, Xiang-Jian Cao, Ming-Yu Chen, Sheng-Wen Hu, Jun-Ying Miao*, Bao-Xiang Zhao*
    An effective colorimetric and ratiometric fluorescent probe for bisulfite in aqueous solution
    Analytica Chimica Acta 888 (2015) 138-145.

  • 5. Xi Dai, Zhao-Yang Wang, Zhi-Fang Du, Jie Cui, Jun-Ying Miao*, Bao-Xiang Zhao*
    A colorimetric, ratiometric and water-soluble fluorescent probe for simultaneously sensing glutathione and cysteine/homocysteine
    Analytica Chimica Acta 900 (2015) 103-110.

  • 6. Yan-Ru Zhang, Peng Su, Jun Huang, Qing-Rong Wang, Bao-Xiang Zhao*
    A magnetic nanomaterial modified with poly-lysine for efficient removal of anionic dyes from water
    Chemical Engineering Journal 262 (2015) 313–318.

  • 7. Xuan Zhang, Shi-Yao Jing, Shu-Ya Huang,Xue-Wen Zhou,Jie-Ming Bai, Bao-Xiang Zhao*
    New fluorescent pH probes for acid conditions
    Sensors and Actuators B 206 (2015) 663–670.

  • 8. Xi Dai,Tao Zhang, Yi-Zhi Liu, Tao Yan, Yun Li, Jun-Ying Miao*,Bao-Xiang Zhao*
    A ratiometric fluorescent probe for cysteine and its application in living cells
    Sensors and Actuators B 207 (2015) 872–877.

  • 9. Xiao-Fan Zhang,Tao Zhang,Shi-Li Shen,Jun-Ying Miao* and Bao-Xiang Zhao*
    A ratiometric lysosomal p H probe based on the coumarin–rhodamine FRET system,

  • RSC Adv.,2015, 5, 49115–49121.

  • 10. Jie Cui, Dong-Peng Li, Shi-Li Shen, Jin-Ting Liu*,Bao-Xiang Zhao*
    A simple and effective fluorescent probe based on rhodamine B for determining Pd2+ ions in aqueous solution
    RSC Adv., 2015, 5, 3875–3880.

  • 11. Shi-Li Shen,Xiao-Fan Zhang, Su-Yun Bai,Jun-Ying Miao*, Bao-Xiang Zhao*
    A novel ratiometric pH probe for extreme acidity based on FRET and PET
    RSC Adv., 2015, 5, 13341–13346.

  • 12. Ying Liu,Sheng-Qing Wang and Bao-Xiang Zhao*
    A novel pyrazoline-based fluorescent probe for detecting fluoride ion in water and its application
    on real samples
    RSC Adv.,2015, 5, 32962–32966.

  • 13. Yan-Ru Zhang, Qing-Rong Wang,Peng Su, Fei Zhao, Jun Huang and Bao-Xiang Zhao*
    A simple yet effective fluorescent probe for detecting and imaging mercury ions in cells
    RSC Adv., 2015, 5, 20634–20638.

  • 14. Xuan Zhang,Guang-Jie Song, Xiang-Jian Cao,Jin-Ting Liu, Ming-Yu Chen, Xiao-Qun Cao and Bao-Xiang Zhao*
    A new fluorescent pH probe for acidic conditions
    RSC Adv., 2015, 5,89827–89832

  • 15. Rong-Rong Zhang, Jin-Feng Zhang, Sheng-Qing Wang, Yan-Long Cheng, Jun-Ying Miao*,Bao-Xiang Zhao*
    Novel pyrazoline-based fluorescent probe for detecting thiols and its application in cells
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 137 (2015) 450–455.

    16. Yu Xu, Xi Dai, Bao-Xiang Zhao*
    A coumarin–indole based colorimetric and "turn on" fluorescent probe for cyanide
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 138 (2015) 164–168.

    17. Xiao-Xin Zheng, Sheng-Qing Wang, Hao-Yan Wang, Rong-Rong Zhang, Jin-Ting Liu*, Bao-Xiang Zhao*
    Novel pyrazoline-based selective fluorescent probe for the detection of hydrazine
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 138 (2015) 247–251.


    18. Rui-Zhe Zhang, Xiao Feng, Ying Liu, Sheng-Qing Wang, Jin-Ting Liu*, Bao-Xiang Zhao*
    Synthesis of novel boron chelate complexes and proposed mechanism of new rearrangement
    Spectrochimica Acta Part A_ Molecular and Biomolecular Spectroscopy 139 (2015) 165–170.

    19. Shuai Zhou, Ze-Quan Zhou, Xuan-Xuan Zhao, Yu-Hao Xiao, Gang Xi, Jin-Ting Liu*, Bao-Xiang Zhao*
    A dansyl based fluorescence chemosensor for Hg2+ and its application in the complicated environment samples
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148 (2015) 348–354.

    20. Xuan-Xuan Zhao,Di Ge, Xi Dai, Wen-Li Wu, Jun-Ying Miao*, Bao-Xiang Zhao*
    A water-soluble pH fluorescence probe based on quaternary ammonium salt for bioanalytical applications
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 151 (2015) 218–224.

    21. Yu-Hao Xiao, Gang Xi, Xuan-Xuan Zhao,Shuai Zhou, Ze-Quan Zhou, Bao-Xiang Zhao*
    A Novel Coumarin-Based Fluorescent Probe for the Detection of Hydrazine Both in Aqueous Solution and Vapor State
    J Fluoresc (2015) 25: 1023–1029.

     2014

  • 1. Yan-Ru Zhang, Xin-Peng Chen, Jing Shao, Jia-Yi Zhang, Qiong Yuan, Jun-Ying Miao and Bao-Xiang Zhao
    A Ratiometric Fluorescent Probe for Sensing HOCl Based on Coumarin-rhodamine Dyad
    Chem. Commun., 50 (2014) 14241–14244

    2. Sheng-Qing Wang, Qing-Hua Wu, Hao-Yan Wang, Xiao-Xin Zheng, Shi-Li Shen, Yan-Ru Zhang, Jun-Ying Miao*, Bao-Xiang Zhao*,
    Novel pyrazoline-based fluorescent probe for detecting glutathione and its application in cells,
    Biosensors and Bioeletronics, 55 (2014) 386–390.

    3. Xi Dai, Qing-Hua Wu, Peng-Chong Wang, Jie Tian, Yu Xu, Sheng-Qing Wang, Jun-Ying Miao, Bao-Xiang Zhao
    A Simple and Effective Coumarin-based Fluorescent Probe for Cysteine,
    Biosensors and Bioeletronics, 59 (2014) 35–39.

    4. Xuan-Xuan Zhao, Jin-Feng Zhang, Wei Liu, Shuai Zhou, Ze-Quan Zhou, Yu-Hao Xiao, Gang Xi, Jun-Ying Miao* and Bao-Xiang Zhao*
    A unique dansyl-based chromogenic chemosensor for rapid and ultrasensitive hydrazine detection
    J. Mater. Chem. B, 2 (2014) 7344-7350.

    5. Yu Xu, Zheng Jiang,  Yu Xiao, Fu-Zhen Bi, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A New Fluorescent pH Probe for Extremely Acidic Conditions.
    Analytica Chimica Acta, 820 (2014) 146–151.

    6. Yu Xu, Zheng Jiang,  Yu Xiao, Ting-Ting  Zhang, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A  new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms.
    Analytica Chimica Acta  807 (2014) 126–134.

    7. Meng-Meng Li, Fang-Wu Wang, Xiao-Yun Wang, Ting-Ting Zhang, Yu Xu,Yu  Xiao, Jun-Ying Miao*, Bao-Xiang Zhao*,
    A new turn-on fl uorescence probe for Zn2+ in aqueous solution and imaging application in living cells.
    Analytica Chimica Acta 826 (2014) 77–83.

    8. Ting-Ting Zhang, Xin-Peng Chen, Jin-Ting Liu,* Liang-Zhong Zhang, Jia-Ming Chu, Le Su* and Bao-Xiang Zhao*
    A high sensitive fluorescence turn-on probe for imaging Zn2+ in aqueous solution and living cells
    RSC Advances, 4 (2014) 16973–16978.

    9. Xuan-Xuan Zhao, Xin-P eng Chen, Shi-Li She, Dong-Peng Li, Shuai Zhou, Ze-Quan Zhou, Yu-Hao Xiao, Gang Xi, Jun- Ying Miao* and Bao-Xiang Zhao*
    A novel pH probe based on rhodamine-rhodanine platform
    RSC Adv., 2014, 4 (92), 50318 - 50324.

    10. Xi Dai, Tao Zhang, Yun Li, Tao Yan, Peng-Chong Wang, Jun-Ying Miao* and Bao-Xian g Zhao*
    An effective fluorescent probe to detect glutathione from other sulfhydryl compounds in aqueous solution and its living cell imaging
    RSC Adv., 2014, 4, 5 4650 –54654.

    11. Su-Yun Bai, Xi Dai, Bao-Xiang Zhao*, Jun-Yi ng Miao*
    Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect.
    RSC Adv., 4 (2014) 19887–19890.

    12. Xue-Wen Zhou, Han-Lin Ma, Xuan Zhang, Shi-Yao Jing, Jun-Ying Miao*, Bao-Xiang Zhao*.
    Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth
    Eur. J. Med. Chem., 79 (2014) 95-101.

    13. Meng Li, Bao-Xiang Zhao*,
    Progress of the synthesis of condense d pyrazole derivatives (from 2010 to mid- 2013).
    Eur. J. Med. Chem., 85 (2014) 311-340.

    14. Jin-Feng Zhang, Meng Li, Jun-Ying Miao*, Bao-Xiang Zhao*
    Biological activities of novel pyrazolyl hydroxamic acid derivatives against human lung cancer cell line A549Original Research Article
    Eur. J. Med. Chem., 83 (2014) 516-525

    15. Fang-Wu Wang, Sheng-Qing Wang, Bao-Xiang Zhao* and Jun-Ying Miao*,
    Discovery of 2-hydroxychalcones as autophagy inducer in A549 lung cancer cells,
    Org. Biomol. Chem., 12 (2014) 3062 –3070.

    16. Yan-Ru Zhang, Shi-Li Shen, Sheng-Qing Wang, Jun Huang, Peng Su, Qing-Rong Wang, Bao-Xiang Zhao*,
    A dual function magnetic nanomaterial modified with lysine for removal of organic dyes from water solution. 
    Chemical Engineering Journal 239 (2014) 250–256.

    17. Hong-Shui Lv, Shu-Ya Huang, Yu Xu, Xi Dai, Jun-Ying Miao*, Bao-Xiang Zhao,*
    A new fluorescent pH probe for imaging lysosomes in living cells.
    Bioorganic & Medicinal Chemistry Letters, 24 (2014) 535–538.

    18. Sheng-Qing Wang, Shu-Yan Liu, Hao-Yan Wang, Xiao-Xin Zheng, Xun Yuan, Yi-Zhi Liu, Jun-Ying Miao*, Bao-Xiang Zhao*,
    Novel Pyrazoline-Based Selective Fluorescent Sensor for Hg2+.
    J Fluoresc. 2014 (24) 657-663.

    2013

    1. Hong-Shui Lv; Shu-Ya Huang; Bao-Xiang Zhao*, Jun-Ying Miao*,
    A new rhodamine B-based lysosomal pH fluorescent indicator.
    Analytica Chimica Acta, 788 (2013) 177– 182.

    2. Wei-Yong Liu, Shi-Li Shen, Hai-Ying Li, Jun-Ying Miao*, Bao-Xiang Zhao*, Fluorescence turn-on chemodosimeter for rapid detection of mercury (II) ions in aqueous solution and blood from mice with toxicosis.
    Analytica Chimica Acta, 791 (2013) 65–71.

    3. Sheng-Qing Wang, Qing-Hua Wu, Hao-Yan Wang, Xiao-Xin Zheng, Shi-Li Shen, Yan-Ru Zhang, Jun-Ying Miao* and Bao-Xiang Zhao*,
    Novel pyrazoline-based selective fluorescent probe for detecting reduced glutathione and its application in living cells and serum.
    Analyst, 2013, 138 , 7169 – 7174.

    4. Shi-Li Shen, Jin-Hui Shao, Ji-Zhuang Luo, Jin-Ting Liu, Jun-Ying Miao*, Bao-Xiang Zhao*, Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives –synthesis, characterization and inhibition against lung cancer cells. Eur. J. Med. Chem, 63 (2013) 256-268.

    5.Ting-Ting Zhang, Fang-Wu Wang,Meng-Meng Li, Jin-Ting Liu, Jun-Ying Miao*, Bao-Xiang Zhao*, A simple pyrazoline-based fluorescent probe for Zn2+ in aqueous solution and imaging in living neuron cells. Sensors & Actuators: B. Chemical, 186 (2013) 755-760.

    6. Hong-Shui Lv, Jing Liu, Jing Zhao, Bao-Xiang Zhao*, Jun-Ying Miao*, Highly Selective and Sensitive pH-Responsive Fluorescent Probe in Living Hela and HUVEC Cells. Sensors and Actuators B 177 (2013) 956– 963.

    7. Fei Ge, Hui Ye, Ji-Zhuang Luo, Sheng Wang, Ya-Jing Sun, Bao-Xiang Zhao*, Jun-Ying Miao*, A New Fluorescent and Colorimetric Chemosensor for Cu(II) Based On Rhodamine Hydrazone and Ferrocene Unit. Sensors and Actuators B, 181 (2013) 215-220.

    8. Hui Ye,  Fei Ge,  Xiao-Cui Chen, Yan Li, He Zhang, Bao-Xiang Zhao*, Jun-Ying Miao*, A new probe for fluorescent recognition of Hg2+ in living cells and colorimetric detection of Cu2+ in aqueous solution. Sensors and Actuators B, 182 (2013)273-279.

    9. Meng Li, Hong-shui Lv, Ji-Zhuang Luo, Jun-Ying Miao*, Bao-Xiang Zhao*, An Effective “Turn-on” Rodamine-based Fluorescent Chemosensor for Cu (II) in Living Cells. Sensors and Actuators B 188 (2013) 1235–1240.

    10. Fei Ge, Hui Ye, He Zhang, Bao-Xiang Zhao*, A novel ratiometric probe based on rhodamine B and coumarin for selective recognition of Fe(Ⅲ) in aqueous solution. Dyes and Pigments, 99 (2013) 661-665.

    11. Dong-Peng Li, Yan-Ru Zhang, Xuan-Xuan Zhao, Bao-Xiang Zhao*, Magnetic nanoparticles coated by aminoguanidine for selective adsorption of acid dyes from aqueous solution. Chemical Engineering Journal 232 (2013) 425–433.

    12. Yan-Ru Zhang, Sheng-Qing Wang, Shi-Li Shen, Bao-Xiang Zhao*, A novel water treatment magnetic nanomaterial for removal of anionic and cationic dyes under severe condition. Chemical Engineering Journal, 233 (2013) 258–264.


    13.  Sheng-Qing Wang, Ying Gao, Hao-Yan Wang, Xiao-Xin Zheng, Shi-Li Shen, Yan-Ru Zhang, Bao-Xiang Zhao*, Synthesis, X-ray Crystal Structure and Optical Properties of Novel 1,3,5-Triarylpyrazoline Derivatives and the Fluorescent Sensor for Cu2+. Spectrochimica Acta Part A, 106 (2013) 110-117.

    14. Hui Ye, Fei Ge Yi-Ming Zhou, Jin-Ting Liu*, Bao-Xiang Zhao*,  A new Schiff base fluorescent probe for imaging Cu2+ in living cells. Spectrochimica Acta Part A, 112 (2013) 132-138.

    15. Meng-Meng Li, Shu-Ya Huang, Hui Ye, Fei Ge, Jun-Ying Miao*, Bao-Xiang Zhao*, A New Pyrazoline-Based Fluorescent Probe for Cu2+ in Live Cells.  J Fluoresc (2013) 23:799–806.

    16. Meng-Meng Li, Wen-Bo Zhao, Ting-Ting Zhang, Wei-Liu Fan, Yu Xu, Yu Xiao, Jun-Ying Miao*, Bao-Xiang Zhao*, A new thiophenyl pyrazoline fluorescent probe for Cu2+ in aqueous solution and imaging in live cell. J Fluoresc, (2013) 23:1263 – 1269.

    17. Shi-Li Shen, Liang-Wen Zheng, Sheng-Qing Wang, Yan-Ru Zhang, Yuan Zhang,Ying-Rui Liu, and Bao-Xiang Zhao*, Solvent-free microwave-assisted synthesis of tetrahydrooxazolo[3,2-a]pyrazolo[1,5-d]pyrazin-5-ones. ARKIVOC 2013 (iv) 44-56. 


    2012

    1. Zhe Zhang, Fang-Wu Wang, Sheng-Qing Wang, Fei Ge, Bao-Xiang Zhao and Jun-Ying Miao, A highly sensitive fluorescent probe based on simple pyrazoline for Zn2+ in living neuron cells. Org. Biomol. Chem., 10 (2012) 8640-8644, Published on 12 September 2012.

    2. Ying-Rui Liu, Ji-Zhuang Luo, Pan-Pan Duan, Jing Shao, Bao-Xiang Zhao, Jun-Ying Miao, Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells. Bioorg. Med. Chem. Letters, 22 (2012) 6882-6887.  Available online 18 September 2012

    3. Hong-Shui Lv, Qian-Qian Han, Xiao-Ling Ding, Ji-Liang Zhou, Pi-Shan Yang, Jun-Ying Miao, and Bao-Xiang Zhao, Synthesis and Discovery of Novel Pyrazole Carboxamide Derivatives as Potential Osteogenesis Inducers. Arch. Pharm. Chem. Life Sci. 2012, 000, 1–8. Article first published online: 26 JUL 2012

    4.Wei-Yong Liu, Hai-Ying Li, Bao-Xiang Zhao and Jun-Ying Miao, A new fluorescent and colorimetric probe for Cu2+ in live cells, Analyst, 2012, 137, 3466.

    5. Shi-Li Shen, Jian Zhu, Meng Li, Bao-Xiang Zhao, Jun-Ying Miao, Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells,
    Eur. J. Med. Chem, 54 (2012) 287-294.

    6. Wei-Yong Liu, Hai-Ying Li, Hong-Shui Lv, Bao-Xiang Zhao, Jun-Ying Miao, A rhodamine chromene-based turn-on fluorescence probe for selectively imaging Cu2+ in living cell. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 95 (2012) 658-663. Available online 26 April 2012

    7. Fei Ge, Meng-Meng Li, Hui Ye, Bao-Xiang Zhao, Effective removal of heavy metal ions (Cd2+, Zn2+, Pb2+, Cu2+) from aqueous solution by polymer modified magnetic nanoparticles, Journal of Hazardous Materials, 211– 212 (2012) 366– 372. 

    8. Fei Ge, Hui Ye, Meng-Meng Li, Bao-Xiang Zhao*. Efficient removal of cationic dyes from aqueous solution by polymer-modified magnetic nanoparticles, Chemical Engineering Journal, 198-199 (2012) 11–17 

    9. Hong-Shui Lv, Xiang-Qian Kong, Qian-Qian Ming, Xing Jin, Jun-Ying Miao, Bao-Xiang Zhao* Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cell. Bioorg. Med. Chem. Letters,  22 (2012) 844–849.

    10. Liang-Wen Zheng, Bao-Xiang Zhao*, and Ying-Rui Liu, Expeditious Synthesis and Single Crystal Structure of New Pyrazole Fused 1,4-Oxazine. J. Heterocyclic Chem.  49 (2012) 691-695.

    11. Zhen-Ju Jiang, Jin-Ting Liu*, Hong-Shui Lv, Bao-Xiang Zhao*, Synthesis, X-ray crystal structure and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012, 86, 181-186.

    12. Liang-Wen Zheng, Hong-Zhuan Xuan, Ying-Rui Liu, Bao-Xiang Zhao, Jin-Ting Liu, Jun-Ying Miao, Facile Synthesis, Single Crystal Structure and Biological Evaluation of Novel Pyrazolo[5,1-d][1,2,5]triazepin-4-ones. Helvetica Chimica Acta, 2012, 95(1) 134-143..

    13. Zhong-Liang Gong, Liang-Wen Zheng, Bao-Xiang Zhao*, Synthesis, X-ray Crystal Structure and Optical Properties Research of Novel Diphenyl Sulfone-based Bis-pyrazoline Derivatives. Journal of Luminescence, 2012, 132, 318-324.

    14. Zhen-Ju Jiang, Hong-Shui Lv, Jian Zhu, Bao-Xiang Zhao,New fluorescent chemosensor based on quinoline and coumarine for Cu2+, Synthetic Metals 162 (2012) 2112– 2116.

    2011

    1. Yingrui Liu, Baoxiang Zhao,* Yonghai Li, Liangwen Zheng, Jinting Liu. Unexpected Rearrangement, A Novel Route to 3–Thiazoline. SYNTHESIS, 2011, 19, 3133-3137.

    2. Zhong-Liang Gong, Fei Ge, Bao-Xiang Zhao. Novel pyrazoline-based selective fluorescent sensor for Zn2+ in aqueous media. Sensors & Actuators: B. Chemical. 2011, 159, 148-153.

    3. Liang-Wen Zheng, Zhong-Liang Gong, Wen-Long Liu, Ying-Rui Liu, Bao-Xiang Zhao. Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2011, 81, 372-379.

    4. Liang-Wen Zheng, Jin-Hui Shao, Bao-Xiang Zhao, Jun-Ying Miao. Synthesis of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells. Bioorg. Med. Chem. Letters. 21 (2011) 3909–3913.

    5. Wei-Yong Liu, Hai-Ying Li, Bao-Xiang Zhao and Jun-Ying Miao. Synthesis, crystal structure and living cell imaging of a Cu2+-specific molecular probe. Org. Biomol. Chem., 2011, 9, 4802-4805.

    6. Song Lian, Jin-Ting Liu, Liang-Wen Zheng, Wei-Yong Liu,and Bao-Xiang Zhao. Synthesis, Structure Characterization, and X-ray Crystallography of Novel 1-Benzyl-3-phenyl-1H-pyrazole-5-carboxylate Derivatives with a Carbohydrate Moiety. Journal of Carbohydrate Chemistry, 2011, 30, 1-15.

    7. Hong-Shui Lv, Yong-Sheng Xie, Wei-Yong Liu, Zhong-Liang Gong, Bao-Xiang Zhao,* Synthesis, X-ray crystal structures and optical properties of novel substituted pyrazoly 1,3,4-oxadiazole derivatives J Fluoresc 2011, 21, 1797-1804.

    8. Zhong-Liang Gong, Bao-Xiang Zhao*, Wei-Yong Liu, Hong-Shui Lv, A new highly selective “turn on” fluorescent sensor for zinc ion based on a pyrazoline derivative, Journal of Photochemistry and Photobiology A: Chemistry 218 (2011) 6–10.

    9. Zhong-Liang Gong, Yong-Sheng Xie, Bao-Xiang Zhao*, Hong-Shui Lv, Wei-Yong Liu,  Liang-Wen Zheng, Song Lian The Synthesis, X-ray Crystal Structure and Optical Properties of Novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline Derivatives, J Fluoresc (2011) 21:355–364.

    10. Ning Liu, Jin-Hua Zhang, Bao-Xiang Zhao*, Jing Zhao, Le Su, Wen-Liang Dong, Shang-Li Zhang, Jun-Ying Miao*Microwave-assisted synthesis, crystal structure of pyrazolo[1,5-a]pyrazin-4(5H)-ones and their selective effects on lung cancer cells. European Journal of Medicinal Chemistry 46 (2011) 2359-2367.

    11. Liang-Wen Zheng and Bao-Xiang Zhao, 6-(4-Chlorophenyl)-2-(4-methoxyphenyl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-oxazine. Acta Cryst. (2011). E67, o1949.

    12. Liang-Wen Zheng, Yin-Rui Liu and Bao-Xiang Zhao, Ethyl 3-(4-chlorophenyl)-1-(2-oxo-2-phenylethyl)-1Hpyrazole-5-carboxylate. Acta Cryst. (2011). E67, o1910–o1911

    13.Zhang Hai-yan, Su Le, Huang Bin, Zhao Jing, Zhao Bao-xiang, Zhang Shang-li, Miao Jun-ying,  N-benzyl-5-phenyl-1H-pyrazole-3-carboxamide promotes vascular endothelial cell angiogenesis and migration in the absence of serum and FGF-2. ACTA PHARMACOLOGICA SINICA   32 (2) 2011, 209-216.

    2010

    1. Liang-Wen Zheng, Jian Zhu, Bao-Xiang Zhao*, Yao-Hui Huang, Jun Ding, Jun-Ying Miao, Synthesis, Crystal Structure And Biological Evaluation Of Novel 2-(5-(Hydroxymethyl)-3-Phenyl-1H-Pyrazol-1-yl)-1-Phenylethanol Derivatives. Eur. J. Med. Chem. 2010, 45, 5792-5799.

    2. Yong-Sheng Xie, Hong-Ling Zhao, Hua Su, Bao-Xiang Zhao*, Jin-Ting Liu, Ji-Kun Li, Hong-Shui Lv, Bai-Shan Wang, Dong-Soo Shin, Jun-Ying Miao. Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. Eur. J. Med. Chem. 45 (2010) 210-218.

    3. ChuanDong Fan, Hua Su, Jing Zhao, BaoXiang Zhao*, ShangLi Zhang, JunYing Miao*, A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin b4 in H322 lung carcinoma cells. Eur. J. Med. Chem. 45, 2010, 1438-1446.

    4. Liang-Wen Zheng, Ying Li, Di Ge, Bao-Xiang Zhao*, Ying-Rui Liu, Hong-Shui Lv, Jun Ding, Jun-Ying Miao. Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells. Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 16, 15 August 2010, Pages 4766-4770.

    5. Hong-Shui Lv, Bao-Xiang Zhao, Ji-Kun Li, Yong Xia, Song Lian, Wei-Yong Liu, Zhong-Liang Gong. The synthesis, characterization and optical properties of novel, substituted, pyrazoly 1,3,4-oxadiazole derivatives. Dyes and Pigments 86 (2010) 25-31.

    6. Wei-Yong Liu, Yong-Sheng Xie, Bao-Xiang Zhao, Bai-Shan Wang, Hong-Shui Lv, Zhong-Liang Gong, Song Lian, Liang-Wen Zheng, The synthesis, x-ray crystal structure and optical properties of novel 5-aryl-1-arylthiazolyl-3-ferrocenyl-pyrazoline derivatives. Journal of Photochemistry and Photobiology A: Chemistry, 214, 2010, 135-144.

    7. Zhong-Liang Gong, Liang-Wen Zheng, Bao-Xiang Zhao*, De-Zhong Yang, Hong-Shui Lv, Wei-Yong Liu, Song Lian. The synthesis, x-ray crystal structure and optical properties of novel 1,3,5-triaryl pyrazoline derivatives. Journal of Photochemistry and Photobiology A: Chemistry 209 (2010) 49-55.

    8. Wei-Yong Liu, Yong-Sheng Xie, Bao-Xiang Zhao, Song Lian, Hong-Shui Lv, Zhong-Liang Gong, Dong-Soo Shin, The synthesis, x-ray crystal structure and optical properties of novel 1-ferrocenyl-2-(5-phenyl-1H-1,2,4-triazol-3-ylthio)ethanone derivatives, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2010, 76 (5), 531-536.

    9. Wei-Yong Liu,a Yong-Sheng Xie, Bai-Shan Wang and Bao-Xiang Zhao*, 2-[5-(1,3-Benzodioxol-5-yl)-3-ferrocenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole, Acta Cryst. (2010). E66, m1275

    2009

    1. Song Lian, Hua Su, Bao-Xiang Zhao*, Wei-Yong Liu, Liang-Wen Zheng, Jun-Ying Miao. Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 7085-7092.

    2. Zheng Liang-Wen, Wu Ling-Ling, Zhao Bao-Xiang*, Dong Wen-Liang, Miao Jun-Ying. Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 1957-1962.

    3. Xiao-Ling Ding, Hai-Yan Zhang, Lei Qi, Bao-Xiang Zhao*, Song Lian, Hong-Shui Lv, Jun-Ying Miao. Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorg. Med. Chem. Letters 19, 2009, 5325-5328.

    4. Wei-Yong Liu, Hai-Ying Li, Bao-Xiang Zhao*, Dong-Soo Shin, Song Lian, Jun-Ying Miao.Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells. Carbohydrate Research 344 (2009) 1270–1275.

    5. Yong-Sheng Xie, Bao-Xiang Zhao*, Hong-Shui Lv, Ji-Kun Li, Bai-Shan Wang, Dong-Soo Shin. Synthesis and single-crystal characterization of novel 2-ferrocenyl-4H-pyrazolo[5,1-c][1,4]oxazin-4-one derivatives. Journal of Molecular Structure 930 (2009) 83–87.

    6. Jin-Hua Zhang, Hua Zuo, Yong-Sheng Xie and Bao-Xiang Zhao*. 2-(4-Chlorophenyl)-5-(3,4-dimethoxyphenethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one. Acta Cryst. (2009). E65, o1457.

    2008

    1. Jin-Hua Zhang, Chuan-Dong Fan, Bao-Xiang Zhao*, Dong-Soo Shin, Wen-Liang Dong, Yong-Sheng Xie, Jun-Ying Miao. Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells. Bioorg. Med. Chem. 16,2008,10165-10171.

    2. Bao-Xiang Zhao*, Lu Zhang, Xing-Shang Zhu, Mao-Sheng Wan, Jing Zhao, Yun Zhang, Shang-Li Zhang, Jun-Ying Miao. Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS and p53 levels in vascular endothelial cells. Bioorg. Med. Chem. 16,2008,5171-5180.

    3. Wen-Liang Dong, Bao-Xiang Zhao*, Fang Wei, Hua Zuo, Dong-Soo Shin. Unexpected Novel Rearrangement Reaction; Synthesis of Benzo-Medium Ring Anhydride. Synthetic Communications 2008, 38, 1224.

    4. Xie Yong-Sheng, Pan Xiao-Hong, Zhao Bao-Xiang*, Liu Jin-Ting, Shin Dong-Soo, Zhang Jin-Hua, Zheng Liang-Wen, Zhao Jing, Miao Jun-Ying. Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.  J. Organometallic Chemistry 693,2008, 1367-1374.

    5. Yong Xia, Chuan-Dong Fan, Bao-Xiang Zhao*, Jing Zhao, Dong-Soo Shin, Jun-Ying Miao. Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells. Eur. J. Med. Chem. 43, 2008, 2347-2353.

    6. Xiao-Hong Pan, Xia Liu, Bao-Xiang Zhao, Yong-Sheng Xie, Dong-Soo Shin, Shang-Li Zhang, Jing Zhao, Jun-Ying Miao. 5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis. Bioorg. Med. Chem. 16, 2008, 9093.

    7. Chuan-Dong Fan, Bao-Xiang Zhao, Fang Wei, Gai-Hua Zhang, Wen-Liang Dong, Jun-Ying Miao. Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivatives. Bioorg. Med. Chem. Letters 18, 2008, 3860-3864.

    8. Wen-Liang Dong, Yan-Qing Ge and Bao-Xiang Zhao. Ethyl 5-(ethoxycarbonyl)-3-(4-methoxyphenyl)-1H-pyrazole-1-acetate. Acta Cryst. (2008). E64, o64.

    9. Jin-Hua Zhang, Wen-Liang Dong, Yan-Qing Ge and Bao-Xiang Zhao. 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one-N-[(E )-1-(2-hydroxy-5-methoxyphenyl)ethylidene]hydrazone. Acta Cryst. (2008). E64, o166.

    2007

    1. Yong Xia, Zhi-Wu Dong, Bao-Xiang Zhao, Xiao Ge, Ning Meng, Dong-Soo Shin, Jun-Ying Miao. Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells. Bioorg. Med. Chem. 2007, 15, 6893-6899.

    2. Qiuxia He, Xingshang Zhu, Mei Shi, Baoxiang Zhao, Jing Zhao, Shangli Zhang and Junying Miao. Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells. Bioorg. Med. Chem. 15 (2007) 3889–3895.

    3. Weiwei Wang, Xia Liu, Yun Zhang, Jing Zhao, Baoxiang Zhao, Shangli Zhang, Junying Miao*. Both senescence and apoptosis induced by deprivation of growth factors were inhibited by a novel butyrolactone derivative through depressing integrinβ4 in vascular endothelial cells. Endothelium. 2007 14(6):325-332.

    4. Zhao J, Zhao BX, Wang WW, Huang B, Zhang SL, Miao JY Phosphatidylcholine-specific phospholipase C and ROS were involved in chicken blastodisc differentiation to vascular endothelial cells. Journal of Cellular Biochemistry 2007,102(2):421-428.

    5. Le Su, BaoXiang Zhao, Xin Lv, Jing Zhao, ShangLi Zhang and JunYing Miao. Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro. Bioorg Med Chem Lett. 2007, 17: 3167-3171.

    6. Le Su, BaoXiang Zhao, Xin Lv, Nan Wang, Jing Zhao, ShangLi Zhang and JunYing Miao,Safrole oxide induces neuronal apoptosis through inhibition of integrin β4/SOD activity and elevation of ROS/NADPH oxidase activity. Life Sciences, 2007, 80, 999-1006.

    7. Weiwei Wang, Xia Liu, Jing Zhao, Baoxiang Zhao, Shangli Zhang and Junying Miao. A novel butyrolactone derivative inhibited apoptosis and depressed integrin ?4 expression in vascular endothelial cells. Bioorg. Med. Chem. Letters 17 (2007) 482–485.

    8. DING, Xiao-Ling; MENG Ning; XIA, Yong; WANG, Li-Juan; ZHANG, Xiao-Feng; ZHAO, Bao-Xiang; MIAO Jun-Ying. Synthesis and bioactivity evaluation of ethyl 1-arylmethyl-3-aryl-1H-pyrazole-5-carboxylate Derivatives. Chin. J. Org. Chem. 2007, 27, 1542-1546. (in Chinese).

    9. ZHAO Bao-xiang, SCHAUDT Marco and BLECHERT Siegfried. Syntheses of Macrocyclic Amides from L-Amino Acid Esters by RCM. CHEM. RES. CHINESE U. 2007, 23 ( 1 ) , 22-30.

    10. DONG Wen-Liang, ZHAO Bao-Xiang, SHIN Doo-Soo, WEI Fang, YAO Wei-Jian, XIA Yong, GE Yan-Qing Synthesis and photochromic properties of 2-(1-benzyl-3-methyl-2-indolylmethylene)-3-isopropylidenesuccinic anhydride. Chin. J. Org. Chem. 2007, 27 (7), 847. (in Chinese).

    11. Fang Wei, Bao-Xiang Zhao, Wen-Liang Dong, Zuo Hua, Dong-Soo Shin, Da-Wei Wang, Yong Xia, Yan-Qing Ge. Microwave-assisted Rapid and Straightforward Synthesis of Novel 6-(Aroxymethyl)-2-aryl-6,7- dihydropyrazolo[5,1-c][1,4]oxazin-4-one Derivatives. Synthetic Communications 2007, 37, 4415-4424.

    12. Wen-Liang Dong, Wei-Jian Yao, Fang Wei and Bao-Xiang Zhao.  (3Z,4Z)-3,4-Bis(1,3-benzodioxol-5-ylmethylene)-tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o2776–o2777.

    13. Wen-Liang Dong, Jin-Hua Zhang, Liang-Wen Zheng and Bao-Xiang Zhao.  (3E,4Z)-3-[(1,3-Benzodioxol-5-yl)methylene]-4-(2-pentylidene)tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3040.

    14. Wen-Liang Dong, Jin-Hua Zhang, Liang-Wen Zheng, Fang Wei and Bao-Xiang Zhao 3-[(1,3-Benzodioxol-6-yl)methylene]-4-(pentan-3-ylidene)tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3066.

    15. Yong Xia, Xiao-Ling Ding, Yan-Qing Ge, Lian-Dong Liu and Bao-Xiang Zhao. Ethyl 1-[(6-chloropyridin-3-yl)methyl]-3-phenyl-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o394–o395.

    16. Yong Xia, Wen-Liang Dong, Yang-Qing Ge, Fang Wei and Bao-Xiang Zhao. Ethyl 1-benzyl-3-(4-chlorophenyl)-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, o1613–o1614.

    17. Yong Xia, Wen-Liang Dong, Xiao-Ling Ding and Bao-Xiang Zhao. Ethyl 1-(4-tert-butylbenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o3257.

    18. Yong Xia, Wen-Liang Dong, Xiao-Ling Ding and Bao-Xiang Zhao. Ethyl 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o3298.

    19 Yong-Sheng Xie, Wen-Liang Dong, Liang-Wen Zheng, Jin-Hua Zhang and Bao-Xiang Zhao. Ethyl 1-(2-bromoethyl)-3-ferrocenyl-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, m978–m979.

    20. Xiao-Ling Ding, Wen-Liang Dong, Yong Xiaa and Bao-Xiang Zhao. 1-(4-tert-Butylbenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3125.

    21. Zheng Tang, Xiao-Ling Ding, Wen-Liang Dong and Bao-Xiang Zhao. 1-(6-Chloropyridin-3-ylmethyl)-3-phenyl-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3348.

    22. Yan-Qing Ge, Yong Xia, Fang Wei, Wen-Liang Dong and Bao-Xiang Zhao.  N-Benzyl-5-phenyl-1H-pyrazole-3-carboxamide. Acta Cryst. (2007). E63, o1186–o1187.

    23. Yan-Qing Ge, Yong Xia, Wen-Liang Dong, Fang Wei and Bao-Xiang Zhao. 2-{5-[N-(4-tert-Butylbenzyl)carbamoyl]-3-phenyl-1H-pyrazol-1-yl}acetic acid. Acta Cryst. (2007) E63, o1287–o1288.

    24. Yan-Qing Ge, Wen-Liang Dong, Yong Xia, Fang Wei and Bao-Xiang Zhao. Ethyl 3-(2-hydroxy-5-methylphenyl)-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, o1313–o1314.

    25. Liang-Wen Zheng, Wen-Liang Dong, Jin-Hua Zhang and Bao-Xiang Zhao. (3E,4E)-3-(1,3-Benzodioxol-5-ylmethylene)-4-(1-phenylethylidene)-tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3567.

    26. Zheng Tang, Xiao-Ling Ding, Wen-Liang Dong and Bao-Xiang Zhao. 1-Benzyl-3-phenyl-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3473.

    2006

    1. Fang Wei, Bao-Xiang Zhao, Bin Huang, Lu Zhang, Chun-Hui Sun, Wen-Liang Dong, Dong-Soo Shin, Jun-Ying Miao. Design, synthesis and preliminary biological evaluation of novel ethyl 1-(2’-hydroxy-3’-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate. Bioorg. Med. Chem. Letters 2006, 16, 6342.

    2. Pei-Fu Jiao, Bao-Xiang Zhao, Wei-Wei Wang, Qiu-Xia He, Mao-Sheng Wan, Dong-Soo Shin, Jun-Ying Miao. Design, synthesis and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives. Bioorg. Med. Chem. Letters 2006, 16, 2862.

    3. ZHAO, Bao-Xiang; SCHAUDT, Marco; BLECHERT, Siegfried. Design and Synthesis of Potential Macrocyclic Zinc Metalloprotease Inhibitors. Chin. J. Chem., 2006, 24, 1080-1085.

    4. Wan Mao-Sheng, Zhao Bao-Xiang, He Qiu-Xia, Jiao Pei-Fu, Wang Da-Wei, Miao Jun-Ying. Synthesis and bioactivity evaluation of ethyl 6-amino-2-substituted-1H-indole-3-carboxylates and their derivatives. Chin. J. Org. Chem. 2006, 26 (9), 1248-1253. (in Chinese).

    5. Nan Wang, Xin Lv, Le Su, BaoXiang Zhao, ShangLi Zhang and JunYing Miao, D609 blocks cell survival and induces apoptosis in neural stem cells. Bioorg. Med. Chem. Letters 16 (2006) 4780–4783.

    6. Chuandong Fan, Weiwei Wang, Baoxiang Zhao, Shangli Zhanga, and Junying Miao. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg. Med. Chem. 2006, 14, 3218-3222.

    7. Le Su, Jing Zhao, Bao Xiang Zhao, Jun Ying Miao, De Ling Yin, Shang Li Zhang, Safrole oxide induced human umbilical vein vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration. BBA-MOL CELL RES 2006, 1763, 247-253.

    8. Du AY, Zhao BX, Yin DL, Zhang SL, Miao JY. Safrole Oxide Induces Apoptosis by Up-regulating Fas and FasL instead of Integrin β4 in A549 Human Lung Cancer Cells. Bioorg. Med. Chem. 2006, 14, 2438-3445.

    9. Wei Tan, Bao-Xiang Zhao, Lei Sha, Pei-Fu Jiao, Mao-Sheng Wan, Lei Su, and Dong-Soo Shin MICROWAVE-ASSISTED RING OPENING OF EPOXIDES IN SOLVENT FREE CONDITIONS. Synthetic Communications 2006, 36 (10), 1353-1359.

    10. TAN, Wei; ZHAO, Bao-Xiang; SHI, Mei; SHA, Lei; MIAO, Jun-Ying; SHIN, Dong-Soo Facile Synthesis and Evaluation of Cell A549 Growth Inhibitory Activity of 4-Aryl-6-aryloxymethylmorpholin-3-one Derivatives. Chin. J. Chem., 2006, 24, 396-400.

    11. SHA, Lei; ZHAO, Bao-Xiang; FAN, Chuan-Dong; TAN, Wei; LI, Xun; MIAO, Jun-Ying. Synthesis and Primary Evaluation of Lung Cancer Cell Growth Inhibitory Activity of Novel 3-Arylmethyl-5-aroxymethylbutyrolactones. Chin. J. Org. Chem. 2006, 26 (4), 537-541.

    12. Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang. Suppressing the Akt/NOS signal pathway and activating Fas protein in bFGF stimulated angiogenesis and VEC growth by Safrole oxide. The international journal of biochemistry and cell biology. 2006, 38,1603-1613.

    13. AiYing Du, BaoXiang Zhao, DeLing Yin, ShangLi Zhang and JunYing Miao, Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells. Bioorg. Med. Chem. Letters 16 (2006) 81–83

    2005

    1. Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang Upregulating of Fas, integrin b4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide. FEBS Letters 2005, 579, 5809–5813

    2. Ai-Ying Du, Bao-Xiang Zhao, De-Ling Yin,c Shang-Li Zhanga and Jun-Ying Miao Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lungcancer cells. Bioorg. Med. Chem. 2005, 13, 4176-4183.

    3. Jing Zhao, Bao-Xiang Zhao, Junying Miao, Shangli Zhang, Deling Yin. Safrole oxide inhibits angiogenesis by inducing apoptosis. Vascular Pharmacology,2005,43, 69-74.

    4. TAN, Wei; ZHAO, Bao-Xiang; SHA, Lei; JIAO, Pei-Fu; WAN, Mao-Sheng; SU, Lei Alumina catalyzed synthesis of β-aminoalcohols from epoxides and aromatic amines. Chin. J. Org. Chem. 2005, 25, 1011-1014. (in Chinese).

    5. Zuo Hua, Zhao Bao-Xiang, Wang Da-Wei, Progress in antidiabetic drugs. China New Drugs 2005, 14(6) 672-678. (in Chinese)

     

【科研项目】

  • 1. 教育部留学回国人员科研启动基金,负责人(1999-)
    2. 山东大学杰出青年科研基金,负责人(1999-)
    3. 山东大学跨学科预研基金, 负责人(2002-)
    4. 山东省自然科学基金重点项目(第二负责人)(2003-2005)
    5. 教育部重点项目,负责人(2004-2006)
    6. 山东省自然科学基金项目,负责人(2006-2008)

    7.山东省科技发展计划科研项目,负责人(2008-2011)

    8. 山东省自然科学基金重点项目,负责人(2008.12-2011.12)

    9. 国家自然科学基金项目(交叉学科化学生物学,主要参加者)(2009-2011)

    10. 国家973前期项目(排名第二)(2009-2011)

    11. 国家自然科学基金,负责人(2010-2012)

    12. 973项目 (骨干)(2010-2014)

  • 13. 山东省自然科学基金项目,负责人(2014.12-2017.12)

  • 14. 山东省科技发展计划项目,负责人(2016-2018)

     
  •  

【科研成果】

  •  
  •  

【所获专利】

  • 20多项授权发明专利。 
  •  

【联合培养情况】

  •  
  •  

【拟招收研究生情况】

  • 培养的研究生适合从事高校教学与科研,报考公务员,开发公司技术开发。

     
  •  
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