• 电话:0531-88364464
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  • 地址:
    中国山东省济南市山大南路27号
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导师风采

【个人简介】

  • 姓名:    王建武
    出生年月:1954年12月25日
    地址:    山东大学化学院,济南,山大南路27号,山东,250100
    电话:    0531- 88362708(o); Moble. 13708920782
    Email:    jwwang@sdu.edu.cn

     
  •  

【学习及工作经历】

  • 教育:
    1994-1993:  New York University,博士后;
    1990-1984: 南开大学,硕士,博士;
    1982-1978: 复旦大学,学士;

  •  
  • 经历:
    1999-今:    山东大学化学系,研究员。2001年起,博士生导师;
    1999-1998:  New York University, 访问教授;
    1998-1997:  山东大学化学系, 副教授;
    1994-1996:  Peptosyn Inc. )研究科学家;
    1993-1990:  天津轻工业化学研究所,高工。

【主讲课程】

  • 有机化学(大本基础课,双语,泰山学堂,化基班);
    有机合成(大本专业课);
    理论有机化学(硕士生专业基础课);
    立体化学与手性合成(博士生专业基础课);
  • 药物设计与合成(博士生专业选修课)。

【研究领域和兴趣】

  •  有机合成:有机合成新反应及新方法。手性合成及功分子合成。天然化合物的全合成及结构修饰;
     药物化学:新药物分子设计、合成及构效关系研究,开发新药。  




【主要论著】


  •  近5年主要论文:
    1. Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles, Datong Zhang, Zongheng Wang, Weiren Xu, Fanggang Sun, Lida Tang, Jianwu Wang,,  European Journal of Medicinal Chemistry,44 (2009) 2202- 2210

  • 2.  A NOVEL AND EFFICIENT APPROACH TO PYRAZOLO[1,5-a]- PYRIDINE DERIVATIVES VIA ONE-POT TANDEM REACTION,  Yan-Qing Ge, Jiong Jia, Yan Li, Ling Yin, and Jianwu Wang* HETEROCYCLES, Vol 78, Issue 1, 2009, pp.197-206

  • 3.  A FACILE APPROACH TO INDOLIZINES VIA TANDEM REACTION, Yan-Qing Ge, Jiong Jia, He Yang, Gui-Long Zhao, Fu-Xu Zhan, and Jianwu Wang*,HETEROCYCLES, Vol. 78, No. 3, 2009, pp. 725 - 736.

  • 4.  Polyphosphoric Acid-Mediated, One-Pot, Novel Reactions to Build Polymethoxyarylnaphthalene Lignans,Guilong Zhao a; Fuxu Zhan b; Zhifeng Wang c; Weiren Xu a; Yuli Wang a; Wei Liu a; Lida Tang d;Jianwu Wang b,Synthetic Communications, 1, 40: 351–360, 2010

  • 5.  FACILE SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINES VIA TANDEM REACTION,Jiong Jia,1,2 Yan-Qing Ge,2 Xu-Tang Tao,1*and Jian-Wu Wang2*,HETEROCYCLES, Vol. 81, No. 1, 2010, pp. 185 - 194.

  • 6.  Synthesis and antimicrobial activities of novel peptide deformylase inhibitors ,Ling Yin,a Wei-Ren Xu,b Zhi-Guo Wang,c Da-Tong Zhang,a Jiong Jia,a Yan-Qing Ge,aYan Li,a and Jian-Wu Wang a*,ARKIVOC 2010 (ix) 196-205

  • 7. Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings,Datong Zhang1,2, Jiong Jia1, Lijuan Meng1, Weiren Xu3, Lida Tang3, and Jianwu Wang1,Arch Pharm Res, 2010,0Vol 33, No 6, 831-842.

  • 8. Design,Synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors, Y L Gao, G L Zhao, W Liu, H Shao, Y L Wang, W R Xu, L D Tang & J W Wang*, Indian Journal of Chemistry, Vol. 49b, November 2010,pp. 1499-1508.

  • 9. The synthesis, characterization and optical properties of novel pyrido[1,2-a]benzimidazole derivatives,Yan Qing Ge a,c,1, Jiong Jia a,b,1, He Yang a, Xu Tang Tao b,*, Jian Wu Wang a,* Dyes and Pigments, 88 (2011), 344-349

  • 10. Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives,He Yang, Yan-Qing Ge, Jiong Jia, Jian-Wu Wang* Journal of Luminescence,131(2011) 749-755

  • 11.  Synthesis, X-ray crystal structure and optical properties of novel 2,5-diaryl-1,3,4-oxadiazole derivatives containing substituted pyrazolo[1,5-a]pyridine units,He Yang, Jinglin Mu, Xia Chen, Lei Feng, Jiong Jia*, Jianwu Wang* Dyes and Pigments,Dyes and PigmentsVolume 91, Issue 3, December 2011, Pages 446-45

  • 12.  Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors,L Yina, J Jiaa, G L Zhaob, W R Xub, L D Tangb & J W Wang*a,Indian Journal of chemistry,2011,50B may, pp695-703

  • 13.  Exquisite Synthesis of a Designed PAR-1 Antagonist, Hua-Ming Miaoa)b), Gui-Long Zhao*b), Lin-Shan Zhangc), Hua Shaob), and Jian-Wu Wang*a) Helvetica Chimica Acta – Vol. 94 (2011) pp 1981-1993

  • 14.  Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors Wang, Yia(王毅) Xu, Weirenb(徐为人) Shao, Huab(邵华) Xie, Yafeia(谢亚非) Wang, Jianwu*,a(王建武) Chin. J. Chem. 2011, 29, 2039—2048

  • 15.  The synthesis, characterization and opticalproperties of novel 1,3,4-oxadiazole containing
    imidazo[1,5-a]pyridinederivatives, Yan Qing Ge a, BenQian Hao a, GuiYun Duan a,, JianWuWang b, Journal of Luminescence 131 (2011) 1070–1076

  • 16.  Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors.   Zhao, Wen Jing; Shi, Yong Heng; Zhao, Gui Long; Wang, Yu Li; Shao, Hua; Li, Da Tang; Wang, Jian Wu.  Chinese Chemical Letters  (2011),  22(10),  1215-1218.   

  • 17.  Synthesis and crystal structure ofethyl1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate.   Wang, Yi; Shao, Hua; Xu, Wei-Ren; Wang, Jian-Wu.   Chinese Journal of Structural Chemistry  (2012),  31(1),  110-114.   

  • 18.  Synthesis, X-ray crystal structure and opticalproperties of novel 2-aryl-3-ethoxycarbonyl-4-
    phenylpyrido[1,2-a]benzimidazoles,  Xia Chen,a He Yang,a Yanqing Ge,c Lei Feng,a Jiong Jiaa,b* andJianwu Wanga* Luminescence (2012), 27(5), 382-389   

  • 19.  新型咖啡酸五环三萜酯的合成与保肝活性,贾炯, 孙学华, 邵腾飞, 金树根, 高月求, 王建武,有机化学 2012, 32 (04), pp 760-764

  • 20.  From Cyclopropenes to Tetrasubstituted Furans: Tandem Isomerization/Alkenylation Sequence with Cu/Pd Relay Catalysis,Chuanling Song, Lin Ju, Mingchao Wang, Pengcheng Liu, Yuanzhe Zhang, Jianwu Wang,* and Zhenghu Xu*[a], Chem. Eur. J. 2013, 19, 3584 – 3589 

  • 21.  A NEW METHOD FOR THE SYNTHESIS OF [1,2,4]TRIAZOLO[1,5-a]-PYRIDINE DERIVATIVES,Wei-Ming Zhao,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c Jiong Jia,a and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp. 869-876. 

  • 22.  SYNTHESIS OF NITROGEN BRIDGEHEAD HETEROCYCLES WITH PHOSPHONATES VIA A NOVEL TANDEM PROCESS,Ya-Fei Xie,a Yan-Qing Ge,a,b Lei Feng,a Hua-Qiang Xu,a Song Meng,a Gui-Long Zhao,c Wei-Ren Xu,c Jiong Jia,a* and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp.815-826. 

  • 23. FACILE SYNTHESIS OF PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES VIA NOVEL TANDEM REACTION INVOLVING HORNER-EMMONS REACTION,Wen-Jing Zhao,a Ya-Fei Xie,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c and Jian-Wu Wanga*HETEROCYCLES, Vol. 87, No. 5, 2013, pp.1121-1126.  

  • 24. Design, synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors, Zhang, Shuo; Wang, Yu-Li; Wei, Qun-Chao; Xu, Wei-Ren; Tang, Li-Da; Zhao, Gui-Long; Wang, Jian-Wu,  Chinese Chemical Letters (2013), 24(5), 429-432.  

  • 25.Dimerization of cyclopropenes to bifurans using tandem metal relay catalysis† Chuanling Song, Di Sun, Xianglong Peng, Jing Bai, Rongyi Zhang, Shengzhen Hou, Jianwu Wang and Zhenghu Xu*  Chem. Commun., 2013, 49, 9167—9169

  • 26.Modular synthesis of all-substituted furans through oxidative carbonylation of cyclopropenes with tandem metal relay catalysis† Chuanling Song, Shuli Dong, Lei Feng, Xianglong Peng, Mingchao Wang,Jianwu Wang and Zhenghu Xu* Org. Biomol. Chem., 2013, 11, 6258–6262

  • 27. Effect of the Substitution Pattern on the Intramolecular Charge-Transfer Emissions in Organoboron-Based Biphenyls, Diphenylacetylenes, and Stilbenes, Yi-Qiao Yan, Yan-Bang Li, Jian-Wu Wang,* and Cui-Hua Zhao*[a] Chem. Asian J. 2013, 8, 3164 – 3176

  • 28. Discovery of 6-Deoxydapagliflozin as a Highly Potent Sodium-dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2Diabetes,Lingyu Zhang1,2, Yuli Wang2, Huaqiang Xu1,2, Yongheng Shi2,3, Bingni Liu2, Qunchao Wei2,Weiren Xu2,3, Lida Tang2,3, Jianwu Wang1* and Guilong Zhao2*Medicinal Chemistry, 2014, 10, 304-317

  • 29.The synthesis, characterization and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(3-butyl-1-chloroimidazo[1,5-a] pyridin-7-yl)-1,3,4-oxadiazole ,Yan Qing Ge a,b, Jiong Jia a, Teng Wanga, Hong Wei Sun c, Gui Yun Duan b, Jian Wu Wang a,⇑Spectrochimica Acta Part A: ,Molecular and Biomolecular Spectroscopy 123 (2014) 336–341
  • 30.Highly emissive dimesitylboryl-substituted 2,1,3-benzothiadiazole derivatives: photophysical properties and efficient fluorescent sensor for fluoride anions,Bin Wang, Hong Pan, Jiong Jia, Yan-Qing Ge, Wen-Qing Cai, Jian-Wu Wang *,Cui-Hua Zhao * Tetrahedron 70 (2014) 5488-5493
     

【科研项目】

  •  1.国家重大基础研究973前期项目1个; PDF柔性模型及其抑制剂先导化合物的研究(2003CCA027).50万元;
     2.山东省科技计划专项2个; a.新型抗生素-扑洛利福乐克星的合 成   2001 ,b.PDF柔性模型及其抑制剂先导化合物的 研究  (032090104),10万元;
     3.山东省自然基金项目:“丙型肝炎病毒NS3/NS4A酶抑制剂的设计、合成及筛选”(Z2004C06), 7万元;
     4.山东省自然基金项目: 氮桥头芳性氮杂五环并吡啶衍生物的  合成与药物研究(Y2008B40)  5万元;
     5.山东省科学技术发展计划项目:新型肽脱甲酰基酶抑制剂类抗生素的研究2009GG20002027  8万元;
     6.与科研院所合作项目6个; 60万元;
     7.与企业合作项目2个。20万元.

【科研成果】

    科研成果:
                       发表科研论文160多篇;
                       承担项目17个(国家级2个,省部级15个);一项产品获部级奖。
                       发明专利15个;
                       医药及其医药中间体开发,十多个项目已应用于企业生产。

【所获专利】


  •  发明专利:
    1 . 一类非肽血管紧张素(AII)受体拮抗剂Jwsartan 化合物及其合成方法与用途,王建武  appl.ZL01107797.2   CN1151150, 2004-05-26
     
    2. 一类PDF酶抑制剂- 异噁唑肟酸系列化合物及其合成方法与用途,王建武、徐为人、王平保、贾炯、任戎、郑晓平、郑洪艳、刘登科、冯勇、李炎、张士俊、任晓文、汤立达, appl. CN20031106927 20031106  ,CN 1613853, 2006.06.21
     
    3. 3-苯基异噁唑-5-甲酰胺基取代β-内酰胺类衍生物及其用途, 王建武 徐为人 王西照 张士俊 吴楠 汤立达,appl. 200510013234,  CN 1687075A  2005.10.26  
     
    4.甘草次酸-30-酰胺类衍生物及其用途   王建武 徐为人 雍建平 汤立达 张士俊 刘利军 王玉丽 任晓文, appl. 200510015371,  CN100488979, 2009-05-20
     
    5. GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF WANG JIANWU; XU WEIREN; YONG JIANPING; TANG LIDA; ZHANG SHIJUN; LIU LIJUN; WANG YULI; REN XIAOWEN ,WO2007041969,2007-04-19
     
    6. 含1,3二杂五元环的异羟肟酸类衍生物及其用途, 王建武、贾炯、徐为人、张大同、汤立达、张士俊、王玉丽、刘巍、李祎亮, appl. CN200710057661.8, 2007.6.19。CN101328156, 2008-12-24
     
    7. 含1,3-二杂苯并五元环的异羟肟酸类衍生物、其制备方法和用途,  王建武;徐为人;贾 炯;张大同;汤立达;刘 巍;张士俊;王玉丽;刘冰妮, appl. CN200810053273.7,  CN  101591298  A  20091202 ,
     
    8. 含异噁唑环的五环三萜-28-羧酸酰胺衍生物、其制备方法和用途.  赵桂龙;王建武;徐为人;汤立达;张士俊;王玉丽;刘 巍 appl. CN200810054105.X , CN101648988 2010.02.17
      
    9. 4-蝶啶氨类化合物及其制备和用途, 段崇刚;王建武;张兰英;宋海波;朱荣秀, appl.  CN200910014795.0, CN101544642,  2009.09.30
     
    10.  酰胺基噻唑衍生物、其制备方法和用途, 赵桂龙、徐为人、李祎亮、邹美香、战付旭、王玉丽、刘巍、张士俊、汤立达、王建武, appl. 200810154154  CN  101445492  2009-06-03
     
    11.  Glycyrrhetinic Acid-30-Amide Derivatives and Their Use  WANG JIANWU; XU WEIREN; YONG JIANPING; TANG LIDA; ZHANG SHIJUN; LIU LIJUN  US2008214636 (A1), 2008-09-04
     
    12.  苯基-3-取代吡唑并[1,5-a] 吡啶(Ⅱ)类衍生物及其制备方法和用途,刘默,刘登科,徐为人,汤立达等, CN  200810052536

    13.   3-o-caffeoyloleane type pentacyclic triterpenoid ester derivative, and preparation method and application thereof.      Gao, Yueqiu; Wang, Jianwu; Jia, Jiong; Sun, Xuehua; Jin, Shugen. .  Faming Zhuanli Shenqing  (2012),     34pp.   CN  102344481

    14.     Preparation of heterocycles useful as antitumor agents and anticoagulants.      Xu, Weiren; Wang, Jianwu; Zhao, Guilong; Zhang, Datong; Tang, Lida; Zhang, Shijun; Wang, Yuli; Liu, Wei; Tan, Chubing; Ren, Xiaowen.     Faming Zhuanli Shenqing  (2010),   22pp.   CN  101768130

    15.     Preparation of heterocycles as antitumor agents and anticoagulants.      Xu, Weiren; Wang, Jianwu; Zhao, Guilong; Zhang, Datong; Tang, Lida; Zhang, Shijun; Wang, Yuli; Liu, Wei; Tan, Chubing; Ren, Xiaowen.    Faming Zhuanli Shenqing  (2010),    16pp.    CN  101768155  

【联合培养情况】

【拟招收研究生情况】

  • 招收研究生情况:
        硕士研究生培养    :1997-2014: 共34人,毕业30人;
        博士研究生培养:    2003-2014: 共20人,毕业15人;
     
        每年拟招收硕士生1-2人、博士研究生1-2人;
     
        本人培养的研究生适合从事工作领域:
        研究型: 进行有机合成及药物合成研究;
        教学型: 进行有机化学及药物化学教学;
        开发型: 进行有机化合物合成及药物中间体合成开发; 
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