• 电话:0531-88364464
  • 传真:0531-88564464
  • 地址:
    中国山东省济南市山大南路27号
  • 邮编:250100

导师风采

【个人简介】

姜玮,男,1962年生人,1984年7月毕业于山东大学化学系,获理学学士学位并留校任教,分别于1992年和2003年在山东大学获理学硕士、博士学位。现任山东大学化学与化工学院教授,博士生导师,学院党委书记,院学术委员会委员,山东大学基础学部学术委员会委员,山东省化学化工学会常务理事,中国化学会会员,中国化学会有机分析专业委员会委员。

0531-88363888(O),wjiang@sdu.edu.cn     

【学习及工作经历】

1984.07 - 1991.12   山东大学化学系,助教

1991.12 - 1997.09   山东大学化学与化工学院,讲师

1997.09 - 2002.09   山东大学化学与化工学院,副教授

2002.09 - 现在         山东大学化学与化工学院,教授

2006.06 - 现在         山东大学化学与化工学院,教授,博士生导师

1999.11 - 2003.12   山东大学化学与化工学院,副院长

2004.01 - 2007.12   山东大学研究生院,副院长

2004.06 - 2007.12   兼任山东大学威海分校研究生处,处长

2007.12 - 2013.01   山东大学化学与化工学院,党委书记兼副院长

2013.01 - 现在         山东大学化学与化工学院,党委书记

【主讲课程】

分析化学前沿,分析化学,无机及分析化学,分析化学实验,仪器分析实验                        

【研究领域和兴趣】

研究领域为生物分析化学,研究工作集中在:
1、DNA纳米材料的设计、制备、表征与功能化;
2、多模态、多维度荧光显微成像技术与单分子检测、单细胞分析;
3、新型荧光信号放大策略与生物分子超灵敏检测技术;
4、新型纳米荧光生物传感器的设计、构建与生物医学应用。
作为项目负责人承担国家自然科学基金面上项目4项,山东省自然科学基金重点项目2项。在Analytical Chemistry,Biomaterials,Chemical Communications,Biosensor and Bioelectronics,ACS Applied Materials & Interfaces,Bioconjugate Chemistry等国际知名学术杂志发表SCI收录研究论文80余篇。

【主要论著】

76. A catalytic assembled enzyme-free three-dimensional DNA walker and its sensing application
Chemical Communications, 2017, 53, 5527--5530
75.Terminal Protection-mediated Autocatalytic Cascade Amplification Coupled with Graphene Oxide Fluorescence Switch for Sensitive and Rapid Detection of Folate Receptor 
Talanta, 2017, Accepted Manuscript
74.A target triggered proximity combination-based fluorescence sensing strategy for adenosine detection
Analyst, 2017, 142, 2247--2252
73.A loop-mediated cascade amplification strategy for highly sensitive detection of DNA methyltransferase activity
Sensors and Actuators B-Chemical, 2017, 244, 599--605
72.Sensitive detection of T4 polynucleotide kinase activity based on multifunctional magnetic probes and polymerization nicking reactions mediated hyperbranched rolling circle amplification
Biosensors and Bioelectronics, 2017, 91, 631--636
71.Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomerase activity
Talanta, 2017, 167, 645--650
70.Toehold-mediated strand displacement reaction-dependent fluorescent strategy for sensitive detection of uracil-DNA glycosylase activity
Biosensors and Bioelectronics, 2017, 89, 984--988
69.Colocalization recognition-activated cascade signal amplification strategy for ultrasensitive detection of transcription factors
Biosensors and Bioelectronics, 2017, 89, 978--983
68.A bicyclo-hairpin probe mediated strand displacement amplification strategy for label-free and sensitive detection of bleomycin
Sensors and Actuators B, 2017, 238, 318–324
67.Model-guided interface probe arrangement for sensitive protein detection
Analytical Chemstry, 2016, 88, 9885--9889
66.Application of an ultrahigh-performance liquid chromatography coupled to quadrupole-Orbitrap high-resolution mass spectrometry for the rapid screening, identification and quantification of illegal adulterated glucocorticoids in herbal medicines
Journal of Chromatography B, 2016, 1038, 34--42
65.Target-controlled gating liposome "off–on"cascade amplification for sensitive and accurate detection of phospholipase D in breast cancer cells with a low-background signal
Chemical Communications, 2016, 52, 10660--10663
64.Binding Induced Colocalization Activated Hybridization Chain Reaction on the Surface of Magnetic Nanobead for Sensitive Detection of Adenosine
Biosensors and Bioelectronics, 2016, 86, 966--970
63.A split recognition mode combined with cascade signal amplification strategy for highly specific, sensitive detection of microRNA
Biosensors and Bioelectronics, 2016, 86, 834--839
62.T-Hg2+-T metallo-base pair-mediated dual amplification fluorescent strategy for the selective and sensitive detection of Hg2+
RSC Advances, 2016, 6, 70984--70989
61.Protein binding-protected DNA three-way junction-mediated rolling circle amplification for sensitive and specific detection of transcription factors
RSC Advances, 2016, 6, 68846–68851
60.Modular nuclease-responsive DNA three-way junctions-based dynamic assembly of DNA device and its sensing application
Analytical Chemistry, 2016, 88, 3817−3825
59.A unique dual recognition hairpin probe mediated fluorescent amplification method for sensitive detection of uracil-DNA glycosylase and endonuclease IV activities
Analyst,2016, 141, 1789–1795
58.Au Nanoparticles Fluorescence Switch-mediated Target Recycling Amplification Strategy for Sensitive Nucleic Acid Detection
RSC Advances, 2016, 6, 10650–10654
57.Cascade Signal Amplification Based on Copper Nanoparticle-Reported Rolling Circle Amplification for Ultrasensitive Electrochemical Detection of the Prostate Cancer Biomarker
ACS Appl. Mater. Interfaces 2016, 8, 2573−2581
56.Multiplexed detection of cytokines based on dual bar-code strategy and single-molecule counting
Analytical Chemistry, 2016, 88, 1578−1584
55.Target-protected dumbbell molecular probe mediated cascade rolling circle amplification strategy for the sensitive assay of DNA methyltransferase activity
Chemical Communications, 2016, 52, 2517--2520
54.A dual amplification fluorescent strategy for sensitive detection of DNA methyltransferase activity based on strand displacement amplification and DNAzyme amplification
Biosensors and Bioelectronics, 2016, 77, 650–655
53.Label-free and enzyme-free detection of transcription factors with graphene oxide fluorescence switch-based multifunctional G-quadruplex-hairpin probe
Biosensors and Bioelectronics,2016, 75, 155–160
52.Label-free detection of nicotinamide adenine dinucleotide based on ligation-triggered exonuclease III-assisted signal amplification
RSC Advances, 2015, 5, 86625–86630
51.Label-free Molecular Beacons-Based Quadratic Isothermal exponential Amplification: A simple and Sensitive One-Pot Method to Detection DNA Methyltransferase Activity
Chemical Communications, 2015, 51, 13538 - 13541
50.Hairpin assembly circuit-based fluorescence cooperative amplification strategy for enzyme-free and label-free detection of small molecule
Talanta, 2015, 143: 101–106
49.FokI cleavage–inhibition strategy for the specific and accurate detection of transcription factors
Talanta, 2015,144, 44–50
48.Label-free and dual-amplified detection of protein via small molecule-ligand linked DNA and a cooperative DNA machine
Biosensors and Bioelectronics, 2015, 72, 107–113
47.Highly selective and sensitive detection of miRNA based on toehold-mediated strand displacement reaction and DNA tetrahedron substrate
Biosensors and Bioelectronics, 2015, 71, 401–406
46.Label-free fluorescence dual-amplified detection of adenosine based on exonucleaseIII-assisted DNA cycling and hybridization chain reaction
Biosensors and Bioelectronics, 2015, 70, 15–20
45.Label-free Nucleic Acid Detection Based on DNA Templated Silver Nanoclusters Fluorescent Probe
Talanta, 2015, 138, 163–168
44.A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity
Biosensors and Bioelectronics, 2015, 68, 654-659
43.A Binding-induced Sutured Toehold Activation for Controllable DNA Strand Displacement Reactions
Chemical Communications, 2015, 51, 2903-2906
42.Sensitive detection of transcription factors with Ag+-stabilized self-assembly triplex DNA molecular switch
Chemical Communications, 2014, 50, 14987-14990
41.Visualizing the endocytosis of phenylephrine in living cells by quantum dot-based tracking
Biomaterials, 2014, 35, 7042-7049
40.Quantitative detection of tumor necrosis factor-α by single molecule counting based on hybridization chain reaction
Biosensors and Bioelectronics, 2014, 60, 180-184
39.Toehold-mediated Strand Displacement Reaction Triggered Isothermal DNA Amplification for Highly Sensitive and Selective Fluorescent Detection of Single-base Mutation
Biosensors and Bioelectronics, 2014, 59, 276-281
38.Cascade Signal Amplification Strategy for Sensitive and Label-free DNA Detection Based on Exo III-catalyzed Recycling Coupled with Rolling Circle Amplification
Analyst, 2014, 139, 2884-2889
37.Aptamer-Based Exonuclease Protection and Enzymatic Recycling Cleavage Amplification Homogeneous Assay for Highly sensitive Detection of thrombin
Analyst, 2014, 139, 3167-3173
36.Quantitative Single-molecule Detection of Protein Based on DNA Tetrahedron Fluorescent Nanolabels
Talanta, 2014, 125, 393-399
35.An ultrasensitive fluorescence assay for protein detection by hybridization chain reaction-based DNA nanotags
Biosensors and Bioelectronics, 2014, 51, 421-425
34.Surface-enhanced Raman spectroscopy detection of polybrominated diphenylethers using a portable Raman spectrometer
Talanta, 2013, 116, 14-17
33.Cysteamine-Modified Silver Nanoparticle Aggregates for Quantitative SERS Sensing of Pentachlorophenol with a Portable Raman Spectrometer
ACS Appl. Mater. Interfaces, 2013, 5 (15), 6902-6908
32.Cysteine-Modulated Colorimetric Sensing of Extracellular Mg2+ in Rat Brain Based on the Strong Chelation Interaction between Dithiothreitol and Mg2+
Analyst, 2013,138, 3046-3052
31.A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP
Chemical Communications, 2013, 49, 2640-2642
30.A Novel Enzyme-free and Label-free Fluorescence Aptasensor for Amplified Detection of Adenosine
Biosensors and Bioelectronics, 2013, 44, 52-56
29.Selective and Sensitive Mercuric (II) Ion Detection Based on Quantum Dots and Nicking Endonuclease Assisted Signal Amplification
Biosensors and Bioelectronics, 2013, 43, 84-87
28.Electrospun porous CuO-Ag nanofibers for quantitative sensitive SERS detection
CrystEngComm, 2013, 15, 1339-1344
27.Visualization the Intracellular Location and Stability of DNA origami with a Label-free Fluorescent Probe
Chemical Communications, 2012, 48, 11301-11303
26.Quantitative Detection of Single DNA Molecules on DNA Tetrahedron Decorated Substrates
Chemical Communications, 2012, 48, 9661-9663
25.In situ fabrication of single-crystalline porous ZnO nanoplates on zinc foil to support silver nanoparticles as a stable SERS substrate
CrystEngComm, 2012, 14, 6023-6028
24.UV Photolysis-induced Generation of Graphene/M (M=Ag/Au) Hybrid Nanomaterials
Materials Letters, 2012, 84, 120-123
23.Silver nanoparticle aggregates on copper foil for reliable quantitative SERS analtsis of polycyclic aromatic hydrocarbons with a portable Raman spectrometer
Analyst, 2012, 137, 3995-4000
22.Micrococcal Nuclease Detection Based on Peptide-Bridged Energy Transfer between Quantum Dots and Dye-Labeled DNA
Talanta, 2012, 97, 533-538
21.Sensitive Detection of Proteins Using Assembled Cascade Fluorescent DNA Nanotags Based on Rolling Circle Amplication
Bioconjugate Chemistry, 2012, 23, 734-739
20.Strong Interaction between Imidazolium-Based Polycationic Polymer and Ferricyanide: toward Redox Potential Regulation for Selective In Vivo Electrochemical Measurements
Analytical Chemistry, 2012, 84, 1900-1906
19.A versatile platform for highly sensitive detection of protein: DNA enriching magnetic nanoparticles based rolling circle amplication immunoassay
Chemical Communications, 2012, 33, 3930-3932.  Inside cover paper
18.Synthesis of a quinazoline derivative: A new a 1-adrenoceptors ligand for conjugation to quantum dots to study a 1-adrenoceptors in living cells
Bioorganic & Medicinal Chemistry Letters, 2011, 21, 5905-5909
17.Label free DNA detection based on gold nanoparticles quenching fluorescence of Rhodamine B
Talanta, 2011, 85, 725-729
16.A Sensitive Enzymatic Method for Paraoxon Detection based on Enzyme Inhibition and Fluorescence Quenching
Talanta, 2011, 84, 400-405
15.Quantitative Detection of Single Molecules Using Enhancement of Dye/DNA Conjugate-Labeled Nanoparticles
Bioconjugate Chemistry, 2010, 21, 1987-1993
14.Solid phase single-molecule counting of antibody binding to supported protein layers surface with low nonspecific adsorption
Talanta, 2010, 82, 1003-1009
13.Fluorescence single-molecule counting assays for protein quantification using epi-fluorescence microscopy  with quantum dots labeling
Analytical Chimica Acta, 2010, 662, 170-176
12.DNA Quantification Based on FRET Realized by Combination with Surfactant CPB
Talanta, 2010, 81, 597-601
11.The co-luminescence effect of a europium(III)-lanthanum(III)-gatifloxacin-sodium dodecylbenzene sulfonate system and its application for the determination of trace amount of europium(III)
Journal of Luminescence, 2010, 130, 591-597
10.Quantitative detection of antibody based on single-molecule counting by total internal reflection fluorescence microscopy with quantum dot labeling
Analytica Chimica Acta, 2009, 634, 83-88
09.Rapid Determination of Minocycline in Pharmaceutical Formulations and Human Urine/Serum Samples Based on the Minocycline-Europium-Sodium Dodecylbenzene Sulfonate Luminescence System
Analytical Letters, 2009, 42, 228-242
08.Luminescence enhancement effect for the determination of balofloxacin with balofloxacin–europium (III)–sodium dodecylbenzene sulfonate system
Journal of Luminescence, 2009, 129, 90-94
07.Micelle-enhanced and terbium-sensitized spectrofluorimetric determination of gatifloxacin and its interaction mechanism
Spectrochimica Acta Part A, 2009, 72, 766-771
06.Rapid determination of gatifloxacin in biological samples and pharmaceutical products using europium-sensitized fluorescence spectrophotometry
Luminescence, 2008, 23, 7-13
05.Quantification of protein based on single-molecule counting by total internal reflection fluorescence microscopy with adsorption equilibrium
Analytica Chimica Acta, 2007, 590, 104-109
04.Fluorimetric Determination of Europium Based on the Co-fluorescence System Eu-Y-Sparfloxacin-SDS
Mikrochimica Acta, 2004, 144, 29-34
03.Determination of trace europium based on a new fluorescence system of europium-sparfloxacin-1,10-phenanthroline-sodium dodecyl sulfate
Analytical Bioanalytical Chemstry, 2003, 377(4), 681-684
02.Spectrofluorimetric determination of trace amounts terbium with 4-chlorsalicylic acid, EDTA, and cetyltrimethylammonium bromide
Analytical Sciences, 2003, 19, 923-925
01.Study of the absorption spectra of the 4f electron transitions of the praseodymium complex with ciprofloxacin and its analytical application



【科研项目】

01.国家基金面上项目:基于功能化石墨烯的循环肿瘤细胞分选与活细胞原位荧光成像研究(No.21675100),2017.01-2020.12,主持

02.国家基金面上项目:基于DNA催化自组装的模块化荧光生物传感技术及其生物医学应用研究 (No.21475077),2015.01-2018.12,主持

03.国家基金面上项目:基于结构DNA纳米材料的生物单分子荧光成像技术研究 (No.21175081),2012.01-2015.12,主持

04.国家基金面上项目:全内反射荧光显微术检测单个生物大分子 (No.20775043),2008.01-2010.12,主持

05.省基金重点项目:量子点结合荧光共振能量转移技术检测生物大分子 (Z2008B05),2009.01-2011.12,主持

06.省基金重点项目:单分子计数及细胞内单分子运动轨迹的观测 (Z2004B03 ),2005.01-2007.12,主持

【科研成果】

【所获专利】

【联合培养情况】

【拟招收研究生情况】

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